Drug resistance among drug-naive and first-line antiretroviral treatment-failing children in Cameroon

Joseph Fokam, Romina Salpini, Maria Mercedes Santoro, Valeria Cento, Carlo Federico Perno, Vittorio Colizzi, Peter Martins Ndumbe, Charles Fokunang Ntungen, Suzie Moyo Ndiang Tetang, Aubin Joseph Nanfack, Désiré Augustin Takou Komego, Giulia Cappelli

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Scale-up to antiretroviral therapy (ART) requires surveillance for HIV drug resistance. With the goal of attaining 100% pediatric ART coverage in Cameroon, strategies to limit the spread of HIV resistance among children are very important. Methods: From June 2009 through February 2011, 92 HIV-1-infected children (41 ART-naive, 51 failing first-line ART) living in Yaoundé, Cameroon, were enrolled; HIV-1 Prot-RT genotypic resistance testing (GRT) was performed using an inhouse assay. Among 40 children failing first-line ART, treatment response was evaluated at weeks 24 and 48 after treatment was changed, based on GRT results. Results: The mean age was 72 months both for children who were drug-naive and those failing ART (range: 3-144 and 12-144, respectively), with a mean viremia of 5.59 log and 4.71 log RNA copies/mL, a median CD4 of 17% (588 cells/μL) and 23% (719 cells/μL), respectively. Median time-to-treatment failure was 610 days. A prevalence of 4.9% and 90% drug resistance was observed, respectively, among children who were drug-naive and those failing first-line ART, with circulating recombinant form CRF02-AG as the most prevalent clade (58.6% and 62%, respectively). After a change to GRT-based treatment, more than 90% of children had viremia

Original languageEnglish
Pages (from-to)1062-1068
Number of pages7
JournalPediatric Infectious Disease Journal
Volume30
Issue number12
DOIs
Publication statusPublished - Dec 2011

Keywords

  • antiretroviral drug resistance
  • Cameroon
  • children
  • human immunodeficiency virus

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Infectious Diseases
  • Microbiology (medical)

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