Drug resistance mutations and newly recognized treatment-related substitutions in the HIV-1 protease gene: Prevalence and associations with drug exposure and real or virtual phenotypic resistance to protease inhibitors in two clinical cohorts of antiretroviral experienced patients

Carlo Torti, Eugenia Quiros-Roldan, Laura Monno, Andrea Patroni, Annalisa Saracino, Gioacchino Angarano, Carmine Tinelli, Sergio Lo Caputo, Valeria Tirelli, Francesco Mazzotta, Giampiero Carosi

Research output: Contribution to journalArticle

Abstract

This study aimed at identifying HIV-1 protease amino acid changes associated with protease inhibitor (PI) exposure and susceptibility. New amino acid substitutions were correlated with the number of experienced Pls, reaching statistical significance only for those at positions 3, 44, and 74. The correspondence multivariate model demonstrated that ≥3 experienced Pls and substitutions or mutations at positions 3, 46, 54, 73, 74, and 84 were correlated with PI cross-resistance, including resistance for lopinavir and amprenavir in this cohort of patients who were naive for these drugs.

Original languageEnglish
Pages (from-to)29-33
Number of pages5
JournalJournal of Medical Virology
Volume74
Issue number1
DOIs
Publication statusPublished - Sep 2004

Keywords

  • Amprenavir
  • Drug resistance
  • HIV-1
  • Interpretation
  • Lopinavir

ASJC Scopus subject areas

  • Virology

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