Drug-resistant bullous pemphigoid and inflammatory bowel disease in a pediatric case successfully treated by plasma exchange and extracorporeal photochemotherapy

Gino Tripodi, Marco Risso, Loredana Tenerini, Paolo Gandullia, Emanuela Castellano, Lucia Rivabella

Research output: Contribution to journalArticlepeer-review

Abstract

Bullous pemphigoid (BP) is an autoimmune skin disease that occurs mainly in elderly patients; onset of BP is rare in childhood. Inflammatory bowel diseases (IBD), by contrast, have a pediatric onset in 25% of presenting cases, requiring expert multidisciplinary management. Here we report a pediatric case of IBD (involving stomach, duodenum, ileum, and colon-rectum) associated with a disseminated form of drug-resistant BP successfully treated by plasma exchange (PEX), extracorporeal photochemotherapy (ECP), and corticosteroid therapy. The addition of PEX and ECP to standard treatment induced no severe side effects, prompted a rapidly achieved complete and long-term remission, and allowed dose tapering of the immunosuppressive drugs over an 18-month follow-up.

Original languageEnglish
Pages (from-to)26-30
Number of pages5
JournalJournal of Clinical Apheresis
Volume22
Issue number1
DOIs
Publication statusPublished - Feb 2007

Keywords

  • Bullous pemphigoid
  • Extracorporeal photochemotherapy
  • Inflammatory bowel disease
  • Pediatrics
  • Plasma exchange

ASJC Scopus subject areas

  • Hematology

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