Abstract
Bullous pemphigoid (BP) is an autoimmune skin disease that occurs mainly in elderly patients; onset of BP is rare in childhood. Inflammatory bowel diseases (IBD), by contrast, have a pediatric onset in 25% of presenting cases, requiring expert multidisciplinary management. Here we report a pediatric case of IBD (involving stomach, duodenum, ileum, and colon-rectum) associated with a disseminated form of drug-resistant BP successfully treated by plasma exchange (PEX), extracorporeal photochemotherapy (ECP), and corticosteroid therapy. The addition of PEX and ECP to standard treatment induced no severe side effects, prompted a rapidly achieved complete and long-term remission, and allowed dose tapering of the immunosuppressive drugs over an 18-month follow-up.
| Original language | English |
|---|---|
| Pages (from-to) | 26-30 |
| Number of pages | 5 |
| Journal | Journal of Clinical Apheresis |
| Volume | 22 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Feb 2007 |
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Keywords
- Bullous pemphigoid
- Extracorporeal photochemotherapy
- Inflammatory bowel disease
- Pediatrics
- Plasma exchange
ASJC Scopus subject areas
- Hematology
Cite this
Drug-resistant bullous pemphigoid and inflammatory bowel disease in a pediatric case successfully treated by plasma exchange and extracorporeal photochemotherapy. / Tripodi, Gino; Risso, Marco; Tenerini, Loredana; Gandullia, Paolo; Castellano, Emanuela; Rivabella, Lucia.
In: Journal of Clinical Apheresis, Vol. 22, No. 1, 02.2007, p. 26-30.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Drug-resistant bullous pemphigoid and inflammatory bowel disease in a pediatric case successfully treated by plasma exchange and extracorporeal photochemotherapy
AU - Tripodi, Gino
AU - Risso, Marco
AU - Tenerini, Loredana
AU - Gandullia, Paolo
AU - Castellano, Emanuela
AU - Rivabella, Lucia
PY - 2007/2
Y1 - 2007/2
N2 - Bullous pemphigoid (BP) is an autoimmune skin disease that occurs mainly in elderly patients; onset of BP is rare in childhood. Inflammatory bowel diseases (IBD), by contrast, have a pediatric onset in 25% of presenting cases, requiring expert multidisciplinary management. Here we report a pediatric case of IBD (involving stomach, duodenum, ileum, and colon-rectum) associated with a disseminated form of drug-resistant BP successfully treated by plasma exchange (PEX), extracorporeal photochemotherapy (ECP), and corticosteroid therapy. The addition of PEX and ECP to standard treatment induced no severe side effects, prompted a rapidly achieved complete and long-term remission, and allowed dose tapering of the immunosuppressive drugs over an 18-month follow-up.
AB - Bullous pemphigoid (BP) is an autoimmune skin disease that occurs mainly in elderly patients; onset of BP is rare in childhood. Inflammatory bowel diseases (IBD), by contrast, have a pediatric onset in 25% of presenting cases, requiring expert multidisciplinary management. Here we report a pediatric case of IBD (involving stomach, duodenum, ileum, and colon-rectum) associated with a disseminated form of drug-resistant BP successfully treated by plasma exchange (PEX), extracorporeal photochemotherapy (ECP), and corticosteroid therapy. The addition of PEX and ECP to standard treatment induced no severe side effects, prompted a rapidly achieved complete and long-term remission, and allowed dose tapering of the immunosuppressive drugs over an 18-month follow-up.
KW - Bullous pemphigoid
KW - Extracorporeal photochemotherapy
KW - Inflammatory bowel disease
KW - Pediatrics
KW - Plasma exchange
UR - http://www.scopus.com/inward/record.url?scp=33947182448&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33947182448&partnerID=8YFLogxK
U2 - 10.1002/jca.20115
DO - 10.1002/jca.20115
M3 - Article
C2 - 17285616
AN - SCOPUS:33947182448
VL - 22
SP - 26
EP - 30
JO - Journal of Clinical Apheresis
JF - Journal of Clinical Apheresis
SN - 0733-2459
IS - 1
ER -