Drug-resistant mutants of HIV-1 in patients exhibiting increasing CD4 cell count despite virological failure of highly active antiretroviral therapy

Andrea Antinori, Giuseppina Liuzzi, Antonella Cingolani, Ada Bertoli, Simona Di Giambenedetto, Maria P. Trotta, Maria G. Rizzo, Enrico Girardi, Adrea De Luca, Carlo F. Perno

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The role of HIV-1 resistance-conferring mutations in predicting discordant viro-immunological responses to highly active antiretroviral therapy was investigated. Reverse transcriptase (RT) M184V, and proteases L24I and V82A were significantly associated with an increased CD4 cell count despite virological failure, whereas RT Y181C reduced the probability of immunorecovery. Lower HIV-1-RNA levels in discordant patients and higher values in those carrying RT Y181C suggested a role of viral replicative capacity. Selected mutations should be considered in evaluating the benefit of continuing therapy in discordant patients.

Original languageEnglish
Pages (from-to)2325-2327
Number of pages3
JournalAIDS (London, England)
Volume15
Issue number17
DOIs
Publication statusPublished - Nov 23 2001

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RNA-Directed DNA Polymerase
Highly Active Antiretroviral Therapy
CD4 Lymphocyte Count
HIV-1
Pharmaceutical Preparations
Mutation
Peptide Hydrolases
RNA
Therapeutics

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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Drug-resistant mutants of HIV-1 in patients exhibiting increasing CD4 cell count despite virological failure of highly active antiretroviral therapy. / Antinori, Andrea; Liuzzi, Giuseppina; Cingolani, Antonella; Bertoli, Ada; Di Giambenedetto, Simona; Trotta, Maria P.; Rizzo, Maria G.; Girardi, Enrico; De Luca, Adrea; Perno, Carlo F.

In: AIDS (London, England), Vol. 15, No. 17, 23.11.2001, p. 2325-2327.

Research output: Contribution to journalArticle

Antinori, Andrea ; Liuzzi, Giuseppina ; Cingolani, Antonella ; Bertoli, Ada ; Di Giambenedetto, Simona ; Trotta, Maria P. ; Rizzo, Maria G. ; Girardi, Enrico ; De Luca, Adrea ; Perno, Carlo F. / Drug-resistant mutants of HIV-1 in patients exhibiting increasing CD4 cell count despite virological failure of highly active antiretroviral therapy. In: AIDS (London, England). 2001 ; Vol. 15, No. 17. pp. 2325-2327.
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AU - Di Giambenedetto, Simona

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AU - De Luca, Adrea

AU - Perno, Carlo F.

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