Abstract
The role of HIV-1 resistance-conferring mutations in predicting discordant viro-immunological responses to highly active antiretroviral therapy was investigated. Reverse transcriptase (RT) M184V, and proteases L24I and V82A were significantly associated with an increased CD4 cell count despite virological failure, whereas RT Y181C reduced the probability of immunorecovery. Lower HIV-1-RNA levels in discordant patients and higher values in those carrying RT Y181C suggested a role of viral replicative capacity. Selected mutations should be considered in evaluating the benefit of continuing therapy in discordant patients.
| Original language | English |
|---|---|
| Pages (from-to) | 2325-2327 |
| Number of pages | 3 |
| Journal | AIDS (London, England) |
| Volume | 15 |
| Issue number | 17 |
| DOIs | |
| Publication status | Published - Nov 23 2001 |
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ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
Cite this
Drug-resistant mutants of HIV-1 in patients exhibiting increasing CD4 cell count despite virological failure of highly active antiretroviral therapy. / Antinori, Andrea; Liuzzi, Giuseppina; Cingolani, Antonella; Bertoli, Ada; Di Giambenedetto, Simona; Trotta, Maria P.; Rizzo, Maria G.; Girardi, Enrico; De Luca, Adrea; Perno, Carlo F.
In: AIDS (London, England), Vol. 15, No. 17, 23.11.2001, p. 2325-2327.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Drug-resistant mutants of HIV-1 in patients exhibiting increasing CD4 cell count despite virological failure of highly active antiretroviral therapy
AU - Antinori, Andrea
AU - Liuzzi, Giuseppina
AU - Cingolani, Antonella
AU - Bertoli, Ada
AU - Di Giambenedetto, Simona
AU - Trotta, Maria P.
AU - Rizzo, Maria G.
AU - Girardi, Enrico
AU - De Luca, Adrea
AU - Perno, Carlo F.
PY - 2001/11/23
Y1 - 2001/11/23
N2 - The role of HIV-1 resistance-conferring mutations in predicting discordant viro-immunological responses to highly active antiretroviral therapy was investigated. Reverse transcriptase (RT) M184V, and proteases L24I and V82A were significantly associated with an increased CD4 cell count despite virological failure, whereas RT Y181C reduced the probability of immunorecovery. Lower HIV-1-RNA levels in discordant patients and higher values in those carrying RT Y181C suggested a role of viral replicative capacity. Selected mutations should be considered in evaluating the benefit of continuing therapy in discordant patients.
AB - The role of HIV-1 resistance-conferring mutations in predicting discordant viro-immunological responses to highly active antiretroviral therapy was investigated. Reverse transcriptase (RT) M184V, and proteases L24I and V82A were significantly associated with an increased CD4 cell count despite virological failure, whereas RT Y181C reduced the probability of immunorecovery. Lower HIV-1-RNA levels in discordant patients and higher values in those carrying RT Y181C suggested a role of viral replicative capacity. Selected mutations should be considered in evaluating the benefit of continuing therapy in discordant patients.
UR - http://www.scopus.com/inward/record.url?scp=0035941384&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035941384&partnerID=8YFLogxK
U2 - 10.1097/00002030-200111230-00017
DO - 10.1097/00002030-200111230-00017
M3 - Article
VL - 15
SP - 2325
EP - 2327
JO - AIDS
JF - AIDS
SN - 0269-9370
IS - 17
ER -