Drug targets to pro-angiogenetic factors with special reference to primary peritoneal mesothelioma

Girolamo Ranieri, Eustachio Ruggieri, Gaetano Falco, Nicola Zizzo, Eliseo Mattioli, Alfredo Francesco Zito, Rosa Patruno, Giampietro Gasparini

Research output: Contribution to journalArticle

Abstract

Angiogenesis is necessary for growth and the spread of human tumors. Animal studies also suggest that angiogenesis an important interspecies biological mechanism of tumor development. Angiogenesis is a complex multistep cascade modulated by both positive soluble factors, such as vascular endothelial growth factor, thymidine phosphorylase, basic-fibroblast growth factor and negative soluble factors such as angiostatin and endostatin. From the endothelial cells of normal tissue. Published studies have suggested that the assessment of microvessel density (MVD) or endothelial area (EA) can be considered as surrogate markers of angiogenesis with biological and prognostic relevance. Literature data on angiogenesis of mesothelioma are inconclusive, with only a few studies performed in primary peritoneal mesothelioma (PPM) due to the rarity of the disease. We assessed immunohistochemically MVD and EA and their biological and clinical significance in a consecutive series of 23 PPM cases. MVD and EA were detected in "hot spots" by a computerized image analyzer. The mean value of MVD and EA was 27 ± 14 and 26.04 ± 8.35 × 10 -2, μ 2 per field (400x), respectively. Patients with a high MVD or EA tumors showed a more clinical aggressiveness due to the presence of ascites and a shorter overall survival. Our results suggest that PPM is an angiogenesis-dependent neoplasia. Therefore, antiangiogenic compounds should be tested particularly in those patients with highly vascularized PPM.

Original languageEnglish
Pages (from-to)271-277
Number of pages7
JournalEndocrine, Metabolic and Immune Disorders - Drug Targets
Volume6
Issue number3
DOIs
Publication statusPublished - Sep 2006

Keywords

  • Endothelial area
  • Image analysis
  • Immunohistochemistry
  • Mesothelioma
  • Microvessel density

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy

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