Abstract
Drug resistance strongly impairs the efficacy of virtually every kind of anticancer therapy. This phenomenon is commonly fueled by intrinsic or acquired mechanisms. In this mini-review, focusing on BRAF-mutated melanoma as prototypical example, we analyze how recent studies that make use of single cell analysis identify the involvement of distinct transcriptional trajectories as the common thread at the basis of drug tolerance. The identification of these transcriptional trajectories provide a mechanistic basis for the development of both intrinsic and acquired drug resistance. These studies also suggest that hitting these transcriptional trajectories through personalized adaptive treatments can delay or abrogate the onset of drug resistance.
Original language | English |
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Article number | 188440 |
Journal | Biochimica et Biophysica Acta - Reviews on Cancer |
Volume | 1874 |
Issue number | 2 |
DOIs | |
Publication status | Published - Dec 2020 |
Keywords
- Drug resistance
- Melanoma
- Tumor heterogeneity
ASJC Scopus subject areas
- Oncology
- Genetics
- Cancer Research