TY - JOUR
T1 - Drug transporters and multiple drug resistance in the most common pediatric solid tumors
AU - Fruci, Doriana
AU - Cho, William C S
AU - Romania, Paolo
AU - Nobili, Valerio
AU - Locatelli, Franco
AU - Alisi, Anna
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Solid tumors account for approximately 30% of all pediatric cancers. Although chemotherapy has largely contributed to strongly improve patient outcome, multidrug resistance (MDR) remains one of the major mechanisms limiting the overall survival. The enhanced efflux rate of chemotherapeutic drugs from tumor cells through drug transporters is one of the most important mechanisms of MDR. Drug transporters play a pivotal role in preserving the balance between sensitivity and resistance of tumor cells to anti-neoplastic drugs. Their functional activities have been barely investigated in pediatric solid malignancies. Here, we provide evidence from the current literatures on drug transporters and MDR in the most common types of pediatric solid tumors, including neuroblas-toma, Wilms' tumor, rhabdomyosarcoma, retinoblastoma, medulloblastoma and hepatoblastoma.
AB - Solid tumors account for approximately 30% of all pediatric cancers. Although chemotherapy has largely contributed to strongly improve patient outcome, multidrug resistance (MDR) remains one of the major mechanisms limiting the overall survival. The enhanced efflux rate of chemotherapeutic drugs from tumor cells through drug transporters is one of the most important mechanisms of MDR. Drug transporters play a pivotal role in preserving the balance between sensitivity and resistance of tumor cells to anti-neoplastic drugs. Their functional activities have been barely investigated in pediatric solid malignancies. Here, we provide evidence from the current literatures on drug transporters and MDR in the most common types of pediatric solid tumors, including neuroblas-toma, Wilms' tumor, rhabdomyosarcoma, retinoblastoma, medulloblastoma and hepatoblastoma.
KW - ABC transporters
KW - MDR1
KW - MRP1
KW - Multidrug resistance
KW - Neoadjuvant chemotherapy
KW - Pediatric solid tumors
UR - http://www.scopus.com/inward/record.url?scp=84961757544&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84961757544&partnerID=8YFLogxK
U2 - 10.2174/1567205010666131212110948
DO - 10.2174/1567205010666131212110948
M3 - Article
AN - SCOPUS:84961757544
VL - 17
SP - 308
EP - 316
JO - Current Drug Metabolism
JF - Current Drug Metabolism
SN - 1389-2002
IS - 4
ER -