Drug transporters and renal drug disposition in the newborn

Simona De Gregori, Manuela De Gregori, Guglielmina Nadia Ranzani, Alessandro Borghesi, Mario Regazzi, Mauro Stronati

Research output: Contribution to journalArticle

Abstract

The individual response to a drug in terms of drug efficacy and toxicity is highly variable; this represents a major problem in clinical practice. Potential causes for such variability include pathogenesis and severity of the disease being treated, drug interactions, patient age, nutritional status, renal and liver function and concomitant illness. Inherited differences in drug metabolism and genetic polymorphism of targets of drug therapy can have even greater influence on the efficacy and toxicity of medications. We will discuss the role of drug transporters organic anion transporting polypeptides and Pgp, drug-related gene polymorphisms and pathologies, renal function and drug metabolism in a very special patient population, the newborn. Reliable predictions of drug pharmacokinetics in the newborn, derived from an understanding of the transport mechanisms, should allow therapeutic agents to be used more safely in this special population.

Original languageEnglish
Pages (from-to)31-37
Number of pages7
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume22
Issue numberSUPPL. 3
DOIs
Publication statusPublished - 2009

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Keywords

  • Genetic polymorphisms
  • Kidneys
  • Newborns
  • Transporters

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

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