Drug Treatment of REM Sleep Behavior Disorders in Dementia with Lewy Bodies

Gloria Massironi, Samantha Galluzzi, Giovanni B. Frisoni

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Dementia with Lewy bodies (DLB) is often associated with REM sleep behavior disorders (RBD) characterized, in contrast to the usual paralysis of REM sleep, by violent motor and verbal activity. Patients and Methods: The pharmacological management of RBD was investigated in three DLB patients treated with clonazepam, a benzodiazepine used as an antiepileptic, or donepezil, a cholinesterase inhibitor. Results: All three patients had marked improvement. The pharmacodynamic mechanisms underlying the efficacy of the two drugs might be due to facilitator effect on the pedunculopontine nucleus, a key structure in the physiology of REM sleep.

Original languageEnglish
Pages (from-to)377-383
Number of pages7
JournalInternational Psychogeriatrics
Volume15
Issue number4
DOIs
Publication statusPublished - Dec 2003

Keywords

  • Clonazepam
  • Dementia with Lewy bodies
  • Donepezil
  • REM sleep
  • Therapy

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Ageing
  • Psychiatry and Mental health
  • Psychology(all)
  • Clinical Psychology

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