Drug Treatment of REM Sleep Behavior Disorders in Dementia with Lewy Bodies

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Background: Dementia with Lewy bodies (DLB) is often associated with REM sleep behavior disorders (RBD) characterized, in contrast to the usual paralysis of REM sleep, by violent motor and verbal activity. Patients and Methods: The pharmacological management of RBD was investigated in three DLB patients treated with clonazepam, a benzodiazepine used as an antiepileptic, or donepezil, a cholinesterase inhibitor. Results: All three patients had marked improvement. The pharmacodynamic mechanisms underlying the efficacy of the two drugs might be due to facilitator effect on the pedunculopontine nucleus, a key structure in the physiology of REM sleep.

Original languageEnglish
Pages (from-to)377-383
Number of pages7
JournalInternational Psychogeriatrics
Volume15
Issue number4
DOIs
Publication statusPublished - Dec 2003

Fingerprint

REM Sleep Behavior Disorder
Lewy Body Disease
REM Sleep
Pharmaceutical Preparations
Clonazepam
Cholinesterase Inhibitors
Benzodiazepines
Paralysis
Anticonvulsants
Motor Activity
Therapeutics
Pharmacology

Keywords

  • Clonazepam
  • Dementia with Lewy bodies
  • Donepezil
  • REM sleep
  • Therapy

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Ageing
  • Psychiatry and Mental health
  • Psychology(all)
  • Clinical Psychology

Cite this

Drug Treatment of REM Sleep Behavior Disorders in Dementia with Lewy Bodies. / Massironi, Gloria; Galluzzi, Samantha; Frisoni, Giovanni B.

In: International Psychogeriatrics, Vol. 15, No. 4, 12.2003, p. 377-383.

Research output: Contribution to journalArticle

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