Drug use and upper gastrointestinal complications in children: A case-control study

Francesca Menniti-Ippolito, Roberto Da Cas, Luciano Sagliocca, Giuseppe Traversa, Fernanda Ferrazin, Carmela Santuccio, Loriana Tartaglia, Francesco Trotta, Pasquale Di Pietro, Salvatore Renna, Rossella Rossi, Bianca Domenichini, Stefania Gamba, Francesco Trovato, Pier Angelo Tovo, Manuela Bianciotto, Carmelina Calitri, Clara Gabiano, Irene Raffaldi, Antonio UrbinoLiviana Da Dalt, Valentina Favero, Laura Giordano, Maura Baraldi, Federica Bertuola, Eleonora Lorenzon, Francesca Parata, Giorgio Perilongo, Silvia Vendramin, Monica Frassineti, Anna Maria Calvani, Elena Chiappini, Maurizio De Martino, Claudia Fancelli, Francesco Mannelli, Rachele Mazzantini, Sara Sollai, Elisabetta Venturini, Nicola Pirozzi, Umberto Raucci, Antonino Reale, Rossella Rossi, Nadia Mores, Giulia Bersani, Alessia De Nisco, Antonio Chiaretti, Riccardo Riccardi, Costantino Romagnoli, Vincenzo Tipo, Michele Dinardo, Teresa Pisapia, Annalisa Capuano, Elisabetta Parretta, Concita Rafaniello, Fortunata Fucà, Eleonora Di Rosa

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To evaluate the risk of upper gastrointestinal complications (UGIC) associated with drug use in the paediatric population. Methods: This study is part of a large Italian prospective multicentre study. The study population included children hospitalised for acute conditions through the emergency departments of eight clinical centres. Patients admitted for UGIC (defined as endoscopically confirmed gastroduodenal lesions or clinically defined haematemesis or melena) comprised the case series; children hospitalised for neurological disorders formed the control group. Information on drug and vaccine exposure was collected through parental interview during the children's hospitalisation. Logistic regression was used to estimate ORs for the occurrence of UGIC associated with drug use adjusted for age, clinical centre and concomitant use of any drug. Results: 486 children hospitalised for UGIC and 1930 for neurological disorders were enrolled between November 1999 and November 2010. Drug use was higher in cases than in controls (73% vs 54%; p

Original languageEnglish
Pages (from-to)218-221
Number of pages4
JournalArchives of Disease in Childhood
Volume98
Issue number3
DOIs
Publication statusPublished - Mar 2013

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

Fingerprint Dive into the research topics of 'Drug use and upper gastrointestinal complications in children: A case-control study'. Together they form a unique fingerprint.

Cite this