Drugs and Brugada syndrome patients: Review of the literature, recommendations, and an up-to-date website (www.brugadadrugs.org)

Pieter G. Postema, Christian Wolpert, Ahmad S. Amin, Vincent Probst, Martin Borggrefe, Dan M. Roden, Silvia G. Priori, Hanno L. Tan, Masayasu Hiraoka, Josep Brugada, Arthur A M Wilde

Research output: Contribution to journalArticle

Abstract

Background: Worldwide, the Brugada syndrome has been recognized as an important cause of sudden cardiac death in individuals at a relatively young age. Importantly, many drugs have been reported to induce the characteristic Brugada syndrome-linked ECG abnormalities and/or (fatal) ventricular tachyarrhythmias. Objective: The purpose of this study was to review the literature on the use of drugs in Brugada syndrome patients, to make recommendations based on the literature and on expert opinion regarding drug safety, and to ensure worldwide online and up-to-date availability of this information to all physicians who treat Brugada syndrome patients. Methods: We performed an extensive review of the literature, formed an international expert panel to produce a consensus recommendation to each drug, and initiated a website (www.brugadadrugs.org). Results: The literature search yielded 506 reports for consideration. Drugs were categorized into one of four categories: (1) drugs to be avoided (n = 18); (2) drugs preferably avoided (n = 23); (3) antiarrhythmic drugs (n = 4); and (4) diagnostic drugs (n = 4). Level of evidence for most associations was C (only consensus opinion of experts, case studies, or standard-of-care) as there are no randomized studies and few nonrandomized studies in Brugada syndrome patients. Conclusion: Many drugs have been associated with adverse events in Brugada syndrome patients. We have initiated a website (www.brugadadrugs.org) to ensure worldwide availability of information on safe drug use in Brugada syndrome patients.

Original languageEnglish
Pages (from-to)1335-1341
Number of pages7
JournalHeart Rhythm
Volume6
Issue number9
DOIs
Publication statusPublished - 2009

Keywords

  • Adverse effects
  • Antiarrhythmic drug
  • Brugada syndrome
  • Drugs
  • Proarrhythmia
  • Sudden cardiac death

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)
  • Medicine(all)

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  • Cite this

    Postema, P. G., Wolpert, C., Amin, A. S., Probst, V., Borggrefe, M., Roden, D. M., Priori, S. G., Tan, H. L., Hiraoka, M., Brugada, J., & Wilde, A. A. M. (2009). Drugs and Brugada syndrome patients: Review of the literature, recommendations, and an up-to-date website (www.brugadadrugs.org). Heart Rhythm, 6(9), 1335-1341. https://doi.org/10.1016/j.hrthm.2009.07.002