Drugs and depression of lymphocyte blastogenesis in children - Trials with Phenilbutazone, Thiamphenicol, Sulfamethopyrazine, Diazepam and the antiblastic platinum diammino dichloride

G. R. Burgio, A. Astaldi, A. Ugazio, G. Biscatti, A. Marchi

Research output: Contribution to journalArticlepeer-review

Abstract

Data are presented which demonstrate an inhibitory effect of non anti-blastic drugs with different therapeutical indications: Phenilbutazone (Ph), Thiamphenicol (Th) and Sulfamethopyrazine (Sl) on PHA and mixed stimulation of normal children peripheral blood lymphocytes, when added in vitro. Similarly a depressed response to PHA was observed for the lymphocytes of patients treated with the same drugs. When tested on the same experimental system, Diazepam (Dz) failed to show a significant inhibition. A first trial with a new antiblastic (cis-platinum II diammino dichloride) has also been performed. The "in vitro" addition of this antiblastic strongly depressed lymphocyte blastogenesis. The viability Trypan-Blue Exclusion Test was performed for all the drugs with inhibiting properties. No citotoxic effect could be seen when the 50% PHA-blastogenesis inhibiting dose was employed.

Original languageEnglish
Pages (from-to)131-139
Number of pages9
JournalZeitschrift für Kinderheilkunde
Volume115
Issue number2
DOIs
Publication statusPublished - Jun 1973

Keywords

  • Blastogenesis-inhibition
  • Drug induced blastogenesis depression
  • Non antiblastic drugs and lymphocyte blastogenesis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)

Fingerprint

Dive into the research topics of 'Drugs and depression of lymphocyte blastogenesis in children - Trials with Phenilbutazone, Thiamphenicol, Sulfamethopyrazine, Diazepam and the antiblastic platinum diammino dichloride'. Together they form a unique fingerprint.

Cite this