Data are presented which demonstrate an inhibitory effect of non anti-blastic drugs with different therapeutical indications: Phenilbutazone (Ph), Thiamphenicol (Th) and Sulfamethopyrazine (Sl) on PHA and mixed stimulation of normal children peripheral blood lymphocytes, when added in vitro. Similarly a depressed response to PHA was observed for the lymphocytes of patients treated with the same drugs. When tested on the same experimental system, Diazepam (Dz) failed to show a significant inhibition. A first trial with a new antiblastic (cis-platinum II diammino dichloride) has also been performed. The "in vitro" addition of this antiblastic strongly depressed lymphocyte blastogenesis. The viability Trypan-Blue Exclusion Test was performed for all the drugs with inhibiting properties. No citotoxic effect could be seen when the 50% PHA-blastogenesis inhibiting dose was employed.
- Drug induced blastogenesis depression
- Non antiblastic drugs and lymphocyte blastogenesis
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health