DTNBP1 haplotype influences baseline assessment scores of schizophrenic in-patients

Chi Un Pae, Antonio Drago, Jung Jin Kim, Ashwin A. Patkar, Tae Youn Jun, Chul Lee, Laura Mandelli, Diana De Ronchi, In Ho Paik, Alessandro Serretti

Research output: Contribution to journalArticle

Abstract

Dysbindin gene (DTNBP1) has been associated with schizophrenia, but literature findings are inconsistent, and further analyses are required. This study is aimed to investigate if a set of DTNBP1 variations might influence clinic psychotic phenotype or treatment response in a sample of 240 Korean schizophrenic in-patients. Four variants have been selected (rs3213207; rs1011313; rs16876759; rs2619522) on the basis of previous findings of association with schizophrenia, bipolar disorder and antidepressant response. Single marker analysis gave marginal results. Haplotype analysis identified a significant association between A-A (rs3213207(A/G), rs1011313(A/G)) haplotype and lower PANSS total and positive scores at baseline (p = 0.01; 0.02) and at discharge (p = 0.008; 0.005). Covariate analysis revealed a more stable significant association between A-A haplotype and baseline scores. These results suggest a protective effect of A-A haplotype on psychotic positive symptoms at baseline.

Original languageEnglish
Pages (from-to)150-154
Number of pages5
JournalNeuroscience Letters
Volume440
Issue number2
DOIs
Publication statusPublished - Aug 1 2008

Keywords

  • Association
  • Dysbindin
  • Gene
  • Schizophrenia

ASJC Scopus subject areas

  • Neuroscience(all)

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    Pae, C. U., Drago, A., Kim, J. J., Patkar, A. A., Jun, T. Y., Lee, C., Mandelli, L., De Ronchi, D., Paik, I. H., & Serretti, A. (2008). DTNBP1 haplotype influences baseline assessment scores of schizophrenic in-patients. Neuroscience Letters, 440(2), 150-154. https://doi.org/10.1016/j.neulet.2008.05.069