TY - JOUR
T1 - Dual effect of verapamil on K+-evoked release of endogenous dopamine from arcuate nucleus-median eminence complex
AU - Di Renzo, Gianfranco
AU - Amoroso, Salvatore
AU - Taglialatela, Maurizio
AU - Annunziato, Lucio
PY - 1984/9/7
Y1 - 1984/9/7
N2 - The effect of verapamil, a calcium-entrance blocker, on K+-evoked release of endogenous dopamine from tuberoinfundibular neurons incubated in vitro was studied. This compound, added to the incubation medium, at the dose of 10-6 M, significantly reinforced K+-induced dopamine release, whereas, at higher doses (10-5, 5 × 10-5 and 10-4 M), it completely prevented the stimulated dopamine release. The results obtained with the higher doses showed the calcium dependence of K+-evoked release of endogenous dopamine from central neurons. The opposite effect, seen with the lower dose of verapamil, could be due to different pharmacological properties of the drug.
AB - The effect of verapamil, a calcium-entrance blocker, on K+-evoked release of endogenous dopamine from tuberoinfundibular neurons incubated in vitro was studied. This compound, added to the incubation medium, at the dose of 10-6 M, significantly reinforced K+-induced dopamine release, whereas, at higher doses (10-5, 5 × 10-5 and 10-4 M), it completely prevented the stimulated dopamine release. The results obtained with the higher doses showed the calcium dependence of K+-evoked release of endogenous dopamine from central neurons. The opposite effect, seen with the lower dose of verapamil, could be due to different pharmacological properties of the drug.
KW - calcium entry blockers
KW - dopamine
KW - dopamine release
KW - tuberoinfundibular dopaminergic neurons
KW - verapamil
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U2 - 10.1016/0304-3940(84)90497-X
DO - 10.1016/0304-3940(84)90497-X
M3 - Article
C2 - 6493631
AN - SCOPUS:0021238076
VL - 50
SP - 269
EP - 272
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 1-3
ER -