Abstract
The effect of verapamil, a calcium-entrance blocker, on K+-evoked release of endogenous dopamine from tuberoinfundibular neurons incubated in vitro was studied. This compound, added to the incubation medium, at the dose of 10-6 M, significantly reinforced K+-induced dopamine release, whereas, at higher doses (10-5, 5 × 10-5 and 10-4 M), it completely prevented the stimulated dopamine release. The results obtained with the higher doses showed the calcium dependence of K+-evoked release of endogenous dopamine from central neurons. The opposite effect, seen with the lower dose of verapamil, could be due to different pharmacological properties of the drug.
| Original language | English |
|---|---|
| Pages (from-to) | 269-272 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 50 |
| Issue number | 1-3 |
| DOIs | |
| Publication status | Published - Sep 7 1984 |
Keywords
- calcium entry blockers
- dopamine
- dopamine release
- tuberoinfundibular dopaminergic neurons
- verapamil
ASJC Scopus subject areas
- Neuroscience(all)
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Cite this
Di Renzo, G., Amoroso, S., Taglialatela, M., & Annunziato, L. (1984). Dual effect of verapamil on K+-evoked release of endogenous dopamine from arcuate nucleus-median eminence complex. Neuroscience Letters, 50(1-3), 269-272. https://doi.org/10.1016/0304-3940(84)90497-X