Dual effect of verapamil on K+-evoked release of endogenous dopamine from arcuate nucleus-median eminence complex

Gianfranco Di Renzo; Salvatore Amoroso; Maurizio Taglialatela; Lucio Annunziato

doi:10.1016/0304-3940(84)90497-X

Dual effect of verapamil on K+-evoked release of endogenous dopamine from arcuate nucleus-median eminence complex

Gianfranco Di Renzo, Salvatore Amoroso, Maurizio Taglialatela, Lucio Annunziato

IRCCS SDN

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of verapamil, a calcium-entrance blocker, on K⁺-evoked release of endogenous dopamine from tuberoinfundibular neurons incubated in vitro was studied. This compound, added to the incubation medium, at the dose of 10^-6 M, significantly reinforced K⁺-induced dopamine release, whereas, at higher doses (10^-5, 5 × 10^-5 and 10^-4 M), it completely prevented the stimulated dopamine release. The results obtained with the higher doses showed the calcium dependence of K⁺-evoked release of endogenous dopamine from central neurons. The opposite effect, seen with the lower dose of verapamil, could be due to different pharmacological properties of the drug.

Original language	English
Pages (from-to)	269-272
Number of pages	4
Journal	Neuroscience Letters
Volume	50
Issue number	1-3
DOIs	https://doi.org/10.1016/0304-3940(84)90497-X
Publication status	Published - Sep 7 1984

Keywords

calcium entry blockers
dopamine
dopamine release
tuberoinfundibular dopaminergic neurons
verapamil

ASJC Scopus subject areas

Neuroscience(all)

Access to Document

10.1016/0304-3940(84)90497-X

Cite this

@article{6272ed685fa441269e41c136be44072b,

title = "Dual effect of verapamil on K+-evoked release of endogenous dopamine from arcuate nucleus-median eminence complex",

abstract = "The effect of verapamil, a calcium-entrance blocker, on K+-evoked release of endogenous dopamine from tuberoinfundibular neurons incubated in vitro was studied. This compound, added to the incubation medium, at the dose of 10-6 M, significantly reinforced K+-induced dopamine release, whereas, at higher doses (10-5, 5 × 10-5 and 10-4 M), it completely prevented the stimulated dopamine release. The results obtained with the higher doses showed the calcium dependence of K+-evoked release of endogenous dopamine from central neurons. The opposite effect, seen with the lower dose of verapamil, could be due to different pharmacological properties of the drug.",

keywords = "calcium entry blockers, dopamine, dopamine release, tuberoinfundibular dopaminergic neurons, verapamil",

author = "{Di Renzo}, Gianfranco and Salvatore Amoroso and Maurizio Taglialatela and Lucio Annunziato",

year = "1984",

month = sep,

day = "7",

doi = "10.1016/0304-3940(84)90497-X",

language = "English",

volume = "50",

pages = "269--272",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "1-3",

}

TY - JOUR

T1 - Dual effect of verapamil on K+-evoked release of endogenous dopamine from arcuate nucleus-median eminence complex

AU - Di Renzo, Gianfranco

AU - Amoroso, Salvatore

AU - Taglialatela, Maurizio

AU - Annunziato, Lucio

PY - 1984/9/7

Y1 - 1984/9/7

N2 - The effect of verapamil, a calcium-entrance blocker, on K+-evoked release of endogenous dopamine from tuberoinfundibular neurons incubated in vitro was studied. This compound, added to the incubation medium, at the dose of 10-6 M, significantly reinforced K+-induced dopamine release, whereas, at higher doses (10-5, 5 × 10-5 and 10-4 M), it completely prevented the stimulated dopamine release. The results obtained with the higher doses showed the calcium dependence of K+-evoked release of endogenous dopamine from central neurons. The opposite effect, seen with the lower dose of verapamil, could be due to different pharmacological properties of the drug.

AB - The effect of verapamil, a calcium-entrance blocker, on K+-evoked release of endogenous dopamine from tuberoinfundibular neurons incubated in vitro was studied. This compound, added to the incubation medium, at the dose of 10-6 M, significantly reinforced K+-induced dopamine release, whereas, at higher doses (10-5, 5 × 10-5 and 10-4 M), it completely prevented the stimulated dopamine release. The results obtained with the higher doses showed the calcium dependence of K+-evoked release of endogenous dopamine from central neurons. The opposite effect, seen with the lower dose of verapamil, could be due to different pharmacological properties of the drug.

KW - calcium entry blockers

KW - dopamine

KW - dopamine release

KW - tuberoinfundibular dopaminergic neurons

KW - verapamil

UR - http://www.scopus.com/inward/record.url?scp=0021238076&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021238076&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(84)90497-X

DO - 10.1016/0304-3940(84)90497-X

M3 - Article

C2 - 6493631

AN - SCOPUS:0021238076

VL - 50

SP - 269

EP - 272

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1-3

ER -

Dual effect of verapamil on K+-evoked release of endogenous dopamine from arcuate nucleus-median eminence complex

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this