Dual effect of verapamil on K+-evoked release of endogenous dopamine from arcuate nucleus-median eminence complex

Gianfranco Di Renzo, Salvatore Amoroso, Maurizio Taglialatela, Lucio Annunziato

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of verapamil, a calcium-entrance blocker, on K+-evoked release of endogenous dopamine from tuberoinfundibular neurons incubated in vitro was studied. This compound, added to the incubation medium, at the dose of 10-6 M, significantly reinforced K+-induced dopamine release, whereas, at higher doses (10-5, 5 × 10-5 and 10-4 M), it completely prevented the stimulated dopamine release. The results obtained with the higher doses showed the calcium dependence of K+-evoked release of endogenous dopamine from central neurons. The opposite effect, seen with the lower dose of verapamil, could be due to different pharmacological properties of the drug.

Original languageEnglish
Pages (from-to)269-272
Number of pages4
JournalNeuroscience Letters
Volume50
Issue number1-3
DOIs
Publication statusPublished - Sep 7 1984

Keywords

  • calcium entry blockers
  • dopamine
  • dopamine release
  • tuberoinfundibular dopaminergic neurons
  • verapamil

ASJC Scopus subject areas

  • Neuroscience(all)

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