Dual rearrangement of immunoglobulin and T-cell receptor gene in a case of T-cell hairy-cell leukemia

A. P. Palumbo, P. Corradini, S. Battaglio, P. Omede, R. Coda, M. Boccadoro, A. Pileri

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Abstract

We report a case of T-ce1l hairy-cell leukemia with a dual rearrangement of Ig- and T-cell receptor genes. The cytochemical, transmission e1ectron microscopy, and surface antigens data (CD3+, CD8+, CD11+, HLA-DR+, CD19-, CD20-) were consistent with a T-cell hairy-cell leukemia. Molecular analysis according to Southern revealed a dual rearrangement of immunoglobulin heavy-chain (JH) and T-cell receptor beta (TcRβ) chain genes. Our findings suggest that the coexistence of JH and TcR gene rearrangements, frequently detected in acute leukemia, may also be observed in hematologic ma1ignancies derived from more differentiated cells.

Original languageEnglish
Pages (from-to)71-76
Number of pages6
JournalEuropean Journal of Haematology
Volume46
Issue number2
Publication statusPublished - 1991

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ASJC Scopus subject areas

  • Hematology

Cite this

Palumbo, A. P., Corradini, P., Battaglio, S., Omede, P., Coda, R., Boccadoro, M., & Pileri, A. (1991). Dual rearrangement of immunoglobulin and T-cell receptor gene in a case of T-cell hairy-cell leukemia. European Journal of Haematology, 46(2), 71-76.