Using monoclonal antibodies to human Vα, we have estimated that up to one-third of mature T-cells express two Vα chains as pat of two functional and independent T-cell receptors. Cells belonging to this dual TCR subset may be specific for a broader range of antigens than cells with a single receptor. We discuss the possibility that dual receptor T-cells may be involved in alloreactivity and autoimmunity.
|Number of pages||5|
|Journal||Annals of the New York Academy of Sciences|
|Publication status||Published - 1995|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)