Dual role of microRNAs in NAFLD

Research output: Contribution to journalArticle

Abstract

MicroRNAs are important post-transcriptional regulators in different pathophysiological processes. They typically affect the mRNA stability or translation finally leading to the repression of target gene expression. Notably, it is thought that microRNAs are crucial for regulating gene expression during metabolic-related disorders, such as nonalcoholic fatty liver disease (NAFLD). Several studies identify specific microRNA expression profiles associated to different histological features of NAFLD, both in animal models and in patients. Therefore, specific assortments of certain microRNAs could have enormous diagnostic potentiality. In addition, microRNAs have also emerged as possible therapeutic targets for the treatment of NAFLD-related liver damage. In this review, we discuss the experimental evidence about microRNAs both as potential non-invasive early diagnostic markers and as novel therapeutic targets in NAFLD and its more severe liver complications.

Original languageEnglish
Pages (from-to)8437-8455
Number of pages19
JournalInternational Journal of Molecular Sciences
Volume14
Issue number4
DOIs
Publication statusPublished - 2013

Fingerprint

MicroRNAs
liver
Liver
gene expression
Gene expression
Gene Expression
animal models
regulators
RNA Stability
Protein Biosynthesis
markers
Non-alcoholic Fatty Liver Disease
Animals
Therapeutics
Animal Models
disorders
damage
Messenger RNA
profiles

Keywords

  • Hepatic fibrosis
  • MicroRNAs
  • NAFLD
  • NASH

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Spectroscopy
  • Inorganic Chemistry
  • Catalysis
  • Molecular Biology
  • Computer Science Applications
  • Medicine(all)

Cite this

Dual role of microRNAs in NAFLD. / Ceccarelli, Sara; Panera, Nadia; Gnani, Daniela; Nobili, Valerio.

In: International Journal of Molecular Sciences, Vol. 14, No. 4, 2013, p. 8437-8455.

Research output: Contribution to journalArticle

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