Dual role of parathyroid hormone in endothelial progenitor cells and marrow stromal mesenchymal stem cells

Giovanni Di Bernardo, Umberto Galderisi, Carmela Fiorito, Tiziana Squillaro, Letizia Cito, Marilena Cipollaro, Antonio Giordano, Claudio Napoli

Research output: Contribution to journalArticle

Abstract

Hematopoietic stem cells derive regulatory information also from parathyroid hormone (PTH). To explore the possibility that PTH may have a role in regulation of other stem cells residing in bone marrow, such as mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs) we assessed the effect of this hormone on the in vitro behavior of MSCs and EPCs. Weevidenced that MSCs were much more responsive to PTH than EPCs. PTH increased the proliferation rate of MSCs with a diminution of senescence and apoptosis. Taken together, our results may suggest a protective effect of PTH on MSCs that reduces stress phenomena and preserve genome integrity. At the opposite, PTH did not modify the fate of EPCs in culture.

Original languageEnglish
Pages (from-to)474-480
Number of pages7
JournalJournal of Cellular Physiology
Volume222
Issue number2
DOIs
Publication statusPublished - Feb 2010

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology
  • Physiology

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