Dual role of PRMT1-dependent arginine methylation in cellular responses to genotoxic stress

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Abstract

We have recently shown that arginine methylation by protein arginine N-methyltransferase 1 (PRMT1) controls the response to cisplatin in ovarian cancer cells. In addition to increased methylation of chromatin proteins that favors senescence-associated secretory phenotype (SASP) activation, our study unraveled global hypo-methylation of RNA-binding proteins, which–we speculate–may promote their phase separation and stress granules formation.

Original languageEnglish
Article number1743808
JournalMolecular and Cellular Oncology
Volume7
Issue number4
DOIs
Publication statusPublished - Jul 3 2020

Keywords

  • Arginine methylation
  • cisplatin
  • LLPS
  • mass spectrometry-based proteomics
  • phosphorylation
  • PRMT1
  • SASP
  • stress granules

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research

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