18F-FDG PET-TC con doppio tempo di acquisizione nella identificazione delle lesioni mammarie

Translated title of the contribution: Dual-time-point [18F]-FDG PET/CT in the diagnostic evaluation of suspicious breast lesions

M. G. Caprio, A. Cangiano, M. Imbriaco, F. Soscia, G. Di Martino, A. Farina, G. Avitabile, L. Pace, P. Forestieri, M. Salvatore

Research output: Contribution to journalArticlepeer-review


Purpose: The authors sought to evaluate whether the reacquisition of images 3 h after administration of radiotracer improves the sensitivity of fluorine-18 fluorodeoxyglucose positron emission tomography computed tomography ([ 18F]-FDG PET/CT) in patients with suspicious breast lesions. Materials and methods: Forty-eight patients with 59 breast lesions underwent an [18F]-FDG PET/CT study in the prone position with a dual-time-point acquisition performed in the early phase 1 h after FDG administration (PET-1) and in the delayed phase 3 h after FDG administration (PET-2). Both examinations were evaluated qualitatively and semiquantitatively with calculation of the mean percentage variation of the standard uptake values (Δ% SUV max) between PET-1 and PET-2. All lesions with an SUVmax ≥2.5 at PET-1 or a reduction in SUV between PET-1 and PET-2 were considered benign. The definitive histopathological diagnosis was available for all patients included in the study. Results: The dual-time-point acquisition of [18F]-FDG PET/CT displayed an accuracy of 85% for lesions with an SUVmax ≥2.5 and/or positive Δ% SUVmax, with sensitivity and specificity values of 81% and 100% compared with 69%, 63% (both pmax of 10±7 (pmax of -21±7 (p18F]-FDG PET/CT in patients with suspicious breast lesions with respect to the single-time-point acquisition. In addition, malignant breast lesions displayed an increase in FDG uptake over time, whereas benign lesions showed a reduction. These variations in FDG uptake between PET-1 and PET-2 are a reliable parameter that can be used for differentiating between benign and malignant breast lesions.

Translated title of the contributionDual-time-point [18F]-FDG PET/CT in the diagnostic evaluation of suspicious breast lesions
Original languageItalian
Pages (from-to)215-224
Number of pages10
JournalRadiologia Medica
Issue number2
Publication statusPublished - Mar 2010

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)


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