Purpose: The authors sought to evaluate whether the reacquisition of images 3 h after administration of radiotracer improves the sensitivity of fluorine-18 fluorodeoxyglucose positron emission tomography computed tomography ([ 18F]-FDG PET/CT) in patients with suspicious breast lesions. Materials and methods: Forty-eight patients with 59 breast lesions underwent an [18F]-FDG PET/CT study in the prone position with a dual-time-point acquisition performed in the early phase 1 h after FDG administration (PET-1) and in the delayed phase 3 h after FDG administration (PET-2). Both examinations were evaluated qualitatively and semiquantitatively with calculation of the mean percentage variation of the standard uptake values (Δ% SUV max) between PET-1 and PET-2. All lesions with an SUVmax ≥2.5 at PET-1 or a reduction in SUV between PET-1 and PET-2 were considered benign. The definitive histopathological diagnosis was available for all patients included in the study. Results: The dual-time-point acquisition of [18F]-FDG PET/CT displayed an accuracy of 85% for lesions with an SUVmax ≥2.5 and/or positive Δ% SUVmax, with sensitivity and specificity values of 81% and 100% compared with 69%, 63% (both pmax of 10±7 (pmax of -21±7 (p18F]-FDG PET/CT in patients with suspicious breast lesions with respect to the single-time-point acquisition. In addition, malignant breast lesions displayed an increase in FDG uptake over time, whereas benign lesions showed a reduction. These variations in FDG uptake between PET-1 and PET-2 are a reliable parameter that can be used for differentiating between benign and malignant breast lesions.
|Translated title of the contribution||Dual-time-point [18F]-FDG PET/CT in the diagnostic evaluation of suspicious breast lesions|
|Number of pages||10|
|Publication status||Published - Mar 2010|
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging