Ductus arteriosus in pulmonary atresia with and without ventricular septal defect: Anatomic and functional differences

Bruno Marino, Paolo Guccione, Adriano Carotti, Andrea De Zorzi, Roberto Di Donato, Carlo Marcelletti

Research output: Contribution to journalArticle


The pulmonary circulation is dependent on the ductus arteriosus in all patients with pulmonary atresia and intact ventricular septum and in some with pulmonary atresia and ventricular septal defect (tetralogy of Fallot type). To assess the time of ductal closure in these two patient categories, we compared the ages at first operation in 58 patients with pulmonary atresia and intact ventricular septum and 32 with pulmonary atresia and septal defect. The age distribution differed significantly between the groups. Whereas 90% of the children with intact ventricular septum required surgery in the first week of life, 50% of those with ventricular septal defect underwent surgery after the first month and 25% after the third month. The previously described and now confirmed anatomic differences of ductus arteriosus or different levels of endogenous prostaglandins may explain persistent patency of the ductus in pulmonary atresia with ventricular septal defect. The phenomenon may have important clinical implications regarding the timing and choise of surgical procedure.

Original languageEnglish
Pages (from-to)93-96
Number of pages4
JournalScandinavian Cardiovascular Journal
Issue number2
Publication statusPublished - 1992



  • Ductus arteriosus
  • Pulmonary atresia
  • Ventricular septal defect

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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