Duodenal gangliocytic paraganglioma, a rare entity among GEP-NET: A case report with immunohistochemical and molecular study

Fabiana Tatangelo, Monica Cantile, Alessia Pelella, Nunzia S. Losito, Giosuè Scognamiglio, Franco Bianco, Andrea Belli, Gerardo Botti

Research output: Contribution to journalArticle

Abstract

Gastroenteropancreatic neuroendocrine tumors are the most incident neuroendocrine tumors. In the new WHO classification (2010) the embryological derivation of each neoplastic entity is one of the most important parameters. Gangliocytic Paraganglioma is a tumor originating in the hindgut, a rare neoplasm, generally affecting the second portion of the duodenum, the majority of which are benign. Cases of gangliocytic paraganglioma with local metastasis or local recurrence have also been reported.We describe a GP in a 48-year-old caucasian male with an unusual site (4th portion of duodenum) and an interesting immunohistochemical and molecular pattern. In particular, we examined the expression of some neuroendocrine markers and a marker of neuronal differentiation, NeuroD1, whose expression can help to better understand the nature of this neoplasia.

Original languageEnglish
Article number54
JournalDiagnostic Pathology
Volume9
Issue number1
DOIs
Publication statusPublished - Mar 12 2014

Keywords

  • Gangliocytic paraganglioma
  • ND markers
  • Neuro D1

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine

Fingerprint Dive into the research topics of 'Duodenal gangliocytic paraganglioma, a rare entity among GEP-NET: A case report with immunohistochemical and molecular study'. Together they form a unique fingerprint.

  • Cite this