Abstract
Gastroenteropancreatic neuroendocrine tumors are the most incident neuroendocrine tumors. In the new WHO classification (2010) the embryological derivation of each neoplastic entity is one of the most important parameters. Gangliocytic Paraganglioma is a tumor originating in the hindgut, a rare neoplasm, generally affecting the second portion of the duodenum, the majority of which are benign. Cases of gangliocytic paraganglioma with local metastasis or local recurrence have also been reported.We describe a GP in a 48-year-old caucasian male with an unusual site (4th portion of duodenum) and an interesting immunohistochemical and molecular pattern. In particular, we examined the expression of some neuroendocrine markers and a marker of neuronal differentiation, NeuroD1, whose expression can help to better understand the nature of this neoplasia.
| Original language | English |
|---|---|
| Article number | 54 |
| Journal | Diagnostic Pathology |
| Volume | 9 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Mar 12 2014 |
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Keywords
- Gangliocytic paraganglioma
- ND markers
- Neuro D1
ASJC Scopus subject areas
- Histology
- Pathology and Forensic Medicine
Cite this
Duodenal gangliocytic paraganglioma, a rare entity among GEP-NET : A case report with immunohistochemical and molecular study. / Tatangelo, Fabiana; Cantile, Monica; Pelella, Alessia; Losito, Nunzia S.; Scognamiglio, Giosuè; Bianco, Franco; Belli, Andrea; Botti, Gerardo.
In: Diagnostic Pathology, Vol. 9, No. 1, 54, 12.03.2014.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Duodenal gangliocytic paraganglioma, a rare entity among GEP-NET
T2 - A case report with immunohistochemical and molecular study
AU - Tatangelo, Fabiana
AU - Cantile, Monica
AU - Pelella, Alessia
AU - Losito, Nunzia S.
AU - Scognamiglio, Giosuè
AU - Bianco, Franco
AU - Belli, Andrea
AU - Botti, Gerardo
PY - 2014/3/12
Y1 - 2014/3/12
N2 - Gastroenteropancreatic neuroendocrine tumors are the most incident neuroendocrine tumors. In the new WHO classification (2010) the embryological derivation of each neoplastic entity is one of the most important parameters. Gangliocytic Paraganglioma is a tumor originating in the hindgut, a rare neoplasm, generally affecting the second portion of the duodenum, the majority of which are benign. Cases of gangliocytic paraganglioma with local metastasis or local recurrence have also been reported.We describe a GP in a 48-year-old caucasian male with an unusual site (4th portion of duodenum) and an interesting immunohistochemical and molecular pattern. In particular, we examined the expression of some neuroendocrine markers and a marker of neuronal differentiation, NeuroD1, whose expression can help to better understand the nature of this neoplasia.
AB - Gastroenteropancreatic neuroendocrine tumors are the most incident neuroendocrine tumors. In the new WHO classification (2010) the embryological derivation of each neoplastic entity is one of the most important parameters. Gangliocytic Paraganglioma is a tumor originating in the hindgut, a rare neoplasm, generally affecting the second portion of the duodenum, the majority of which are benign. Cases of gangliocytic paraganglioma with local metastasis or local recurrence have also been reported.We describe a GP in a 48-year-old caucasian male with an unusual site (4th portion of duodenum) and an interesting immunohistochemical and molecular pattern. In particular, we examined the expression of some neuroendocrine markers and a marker of neuronal differentiation, NeuroD1, whose expression can help to better understand the nature of this neoplasia.
KW - Gangliocytic paraganglioma
KW - ND markers
KW - Neuro D1
UR - http://www.scopus.com/inward/record.url?scp=84901985768&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84901985768&partnerID=8YFLogxK
U2 - 10.1186/1746-1596-9-54
DO - 10.1186/1746-1596-9-54
M3 - Article
C2 - 24621010
AN - SCOPUS:84901985768
VL - 9
JO - Diagnostic Pathology
JF - Diagnostic Pathology
SN - 1746-1596
IS - 1
M1 - 54
ER -