Duodenogastric reflux

Correlations among bile acid pattern, mucus secretion, and mucosal damage

E. Masci, P. A. Testoni, L. Fanti, M. Guslandi, M. Zuin, A. Tittobello

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Forty-five patients with bile reflux at endoscopic examination, confirmed by titration of bile acids in gastric juice, were admitted to the study and divided into three groups in accordance with histologic results: normal findings, chronic superficial gastritis, and chronic atrophic gastritis. Bile acid pattern was determined in duodenal samples by high-performance liquid chromatography titration, and the mucoprotein content of gastric juice was assessed. The results of qualitative analysis of bile acid showed an increase of deoxycholic acid in patients with atrophic gastritis (p <0.05) in comparison with controls: determination of taurine and glycine conjugates showed an increase of taurodeoxycholic acid in patients with atrophic gastritis (p <0.01) compared with controls. The composition of mucus was altered only in patients with atrophic gastritis. Whether the increase in deoxycholic acid in biliary reflux is a factor in the development of chronic atrophic gastritis or is secondary to the increase of gastric pH. detectable in this condition, is still uncertain. However, the increase of deoxycholic acid and its taurine conjugates may be a factor that leads to persistence of mucosal lesions.

Original languageEnglish
Pages (from-to)308-312
Number of pages5
JournalScandinavian Journal of Gastroenterology
Volume22
Issue number3
DOIs
Publication statusPublished - 1987

Fingerprint

Duodenogastric Reflux
Atrophic Gastritis
Mucus
Bile Acids and Salts
Deoxycholic Acid
Gastric Juice
Taurine
Taurodeoxycholic Acid
Bile Reflux
Mucoproteins
Gastritis
Glycine
Stomach
High Pressure Liquid Chromatography

Keywords

  • Bile acid pattern
  • Bile reflux
  • Chronic gastritis
  • Mucus secretion

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Duodenogastric reflux : Correlations among bile acid pattern, mucus secretion, and mucosal damage. / Masci, E.; Testoni, P. A.; Fanti, L.; Guslandi, M.; Zuin, M.; Tittobello, A.

In: Scandinavian Journal of Gastroenterology, Vol. 22, No. 3, 1987, p. 308-312.

Research output: Contribution to journalArticle

Masci, E. ; Testoni, P. A. ; Fanti, L. ; Guslandi, M. ; Zuin, M. ; Tittobello, A. / Duodenogastric reflux : Correlations among bile acid pattern, mucus secretion, and mucosal damage. In: Scandinavian Journal of Gastroenterology. 1987 ; Vol. 22, No. 3. pp. 308-312.
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