Durable and complete hematopoietic reconstitution after autografting of rhGM-CSF exposed peripheral blood progenitor cells

A. M. Gianni, C. Tarella, S. Siena, M. Bregni, M. F. Boccadoro Lombardi, C. Bengala, G. Bonadonna, A. Pileri

Research output: Contribution to journalArticle

Abstract

Two patients with poor prognosis stage III multiple myeloma have been treated with myeloablative chemoradiotherapy, i.e. 10 Gy fractionated total body irradiation plus 120 mg/m2 intravenous melphalan, and then transplanted with autologous peripheral blood cells harvested by four leukaphereses during the phase of rapid hematopoietic recovery following induction therapy with high-dose (2 g/m2) etoposide and recombinant human glycosylated granulocyte macrophage-colony stimulating factor (rhGM-CSF). Following myeloablative therapy and autologous peripheral blood cell transplantation, both patients experienced brief pancytopenia followed by rapid hematopoietic recovery of leukocytes (time to >500 x 106/I=12 days) and platelets (time to > 100 x 109/l=14 days). In particular, single donor platelet transfusion requirements were limited to one and two transfusions per patient, respectively. Reconstitution has so far been maintained throughout the follow-up period for the two patients (9 and 6 months, respectively). These two cases show that rhGM-CSF-exposed peripheral blood cells are capable of producting prompt and sustained hematopoietic reconstitution in patients treated with myeloablative chemoradiotherapy.

Original languageEnglish
Pages (from-to)143-145
Number of pages3
JournalBone Marrow Transplantation
Volume6
Issue number2
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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    Gianni, A. M., Tarella, C., Siena, S., Bregni, M., Boccadoro Lombardi, M. F., Bengala, C., Bonadonna, G., & Pileri, A. (1990). Durable and complete hematopoietic reconstitution after autografting of rhGM-CSF exposed peripheral blood progenitor cells. Bone Marrow Transplantation, 6(2), 143-145.