Duration of exposure to environmental carcinogens affects DNA-adduct level in human lymphocytes

Alberto Izzotti, Alessandra Pulliero, Riccardo Puntoni, Marco Peluso, Rosangela Filiberti, Armelle Munnia, Giorgio Assennato, Giovanni Ferri, Domenico Franco Merlo

Research output: Contribution to journalArticle

Abstract

Background and objective: An important issue in human biomonitoring is determining how exposure duration affects the kinetics of molecular biomarkers. In this study we compare the influence of exposure variables on DNA adducts. Methods: DNA adducts were analysed by 32P-postlabelling in lympho/monocytes of 677 Caucasian subjects. Results: After correction for other variables, DNA adducts increased depending on the length of occupational and smoke exposures. Higher DNA adducts were detected in workers with more than 14 years of exposure than in workers with shorter exposures (RR1=.19, p=0.049) and in smokers with more than 10 years of exposure than in smokers with shorter exposure (RR=1.21, p

Original languageEnglish
Pages (from-to)575-582
Number of pages8
JournalBiomarkers
Volume15
Issue number7
DOIs
Publication statusPublished - Nov 2010

Keywords

  • Chronic exposure
  • DNA adducts
  • Human biomonitoring

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis

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    Izzotti, A., Pulliero, A., Puntoni, R., Peluso, M., Filiberti, R., Munnia, A., Assennato, G., Ferri, G., & Merlo, D. F. (2010). Duration of exposure to environmental carcinogens affects DNA-adduct level in human lymphocytes. Biomarkers, 15(7), 575-582. https://doi.org/10.3109/1354750X.2010.497870