Abstract
Background and Aims: The relationship between celiac disease and many autoimmune disorders has been explained by the sharing of a common genetic factor. In a multicenter national study, we examined the relationship between the prevalence of autoimmune disorders in celiac disease and the duration of exposure to gluten. Methods: Over a 6-month period, 909 patients with celiac disease (group A; mean age, 16.1 ± 3.8 years; grouped according to age at diagnosis into three subgroups [group A1, 10 years]), 1268 healthy controls (group B; mean age, 20.8 ± 4.5 years), and 163 patients with Crohn's disease (group C; mean age, 28.8 ± 10 years) were evaluated for the presence of autoimmune disorders. Results: Prevalence of autoimmune disorders in group A was significantly higher than in group B (14% vs. 2.8%; P <0.000001) but not higher than in group C (12.9%). Prevalence of autoimmune disorders in celiac disease increased with increasing age at diagnosis: 5.1% in group A1, 17% in group A2, and 23.6% in group A3 (P = 0.000001). In group A3, the prevalence of autoimmune disorders was significantly higher than in group C. In a logistic regression model, age at diagnosis was the only significant predictor variable of the odds of developing an autoimmune disorder (r = 0.3; P <0.000001). Conclusions: Our data show for the first time that the prevalence of autoimmune disorders in celiac disease is related to the duration of exposure to gluten.
| Original language | English |
|---|---|
| Pages (from-to) | 297-303 |
| Number of pages | 7 |
| Journal | Gastroenterology |
| Volume | 117 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1999 |
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ASJC Scopus subject areas
- Gastroenterology
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Duration of exposure to gluten and risk for autoimmune disorders in patients with celiac disease. / Ventura, A.; Magazzu, G.; Greco, L.
In: Gastroenterology, Vol. 117, No. 2, 1999, p. 297-303.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Duration of exposure to gluten and risk for autoimmune disorders in patients with celiac disease
AU - Ventura, A.
AU - Magazzu, G.
AU - Greco, L.
PY - 1999
Y1 - 1999
N2 - Background and Aims: The relationship between celiac disease and many autoimmune disorders has been explained by the sharing of a common genetic factor. In a multicenter national study, we examined the relationship between the prevalence of autoimmune disorders in celiac disease and the duration of exposure to gluten. Methods: Over a 6-month period, 909 patients with celiac disease (group A; mean age, 16.1 ± 3.8 years; grouped according to age at diagnosis into three subgroups [group A1, 10 years]), 1268 healthy controls (group B; mean age, 20.8 ± 4.5 years), and 163 patients with Crohn's disease (group C; mean age, 28.8 ± 10 years) were evaluated for the presence of autoimmune disorders. Results: Prevalence of autoimmune disorders in group A was significantly higher than in group B (14% vs. 2.8%; P <0.000001) but not higher than in group C (12.9%). Prevalence of autoimmune disorders in celiac disease increased with increasing age at diagnosis: 5.1% in group A1, 17% in group A2, and 23.6% in group A3 (P = 0.000001). In group A3, the prevalence of autoimmune disorders was significantly higher than in group C. In a logistic regression model, age at diagnosis was the only significant predictor variable of the odds of developing an autoimmune disorder (r = 0.3; P <0.000001). Conclusions: Our data show for the first time that the prevalence of autoimmune disorders in celiac disease is related to the duration of exposure to gluten.
AB - Background and Aims: The relationship between celiac disease and many autoimmune disorders has been explained by the sharing of a common genetic factor. In a multicenter national study, we examined the relationship between the prevalence of autoimmune disorders in celiac disease and the duration of exposure to gluten. Methods: Over a 6-month period, 909 patients with celiac disease (group A; mean age, 16.1 ± 3.8 years; grouped according to age at diagnosis into three subgroups [group A1, 10 years]), 1268 healthy controls (group B; mean age, 20.8 ± 4.5 years), and 163 patients with Crohn's disease (group C; mean age, 28.8 ± 10 years) were evaluated for the presence of autoimmune disorders. Results: Prevalence of autoimmune disorders in group A was significantly higher than in group B (14% vs. 2.8%; P <0.000001) but not higher than in group C (12.9%). Prevalence of autoimmune disorders in celiac disease increased with increasing age at diagnosis: 5.1% in group A1, 17% in group A2, and 23.6% in group A3 (P = 0.000001). In group A3, the prevalence of autoimmune disorders was significantly higher than in group C. In a logistic regression model, age at diagnosis was the only significant predictor variable of the odds of developing an autoimmune disorder (r = 0.3; P <0.000001). Conclusions: Our data show for the first time that the prevalence of autoimmune disorders in celiac disease is related to the duration of exposure to gluten.
UR - http://www.scopus.com/inward/record.url?scp=0032806274&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032806274&partnerID=8YFLogxK
U2 - 10.1053/gast.1999.0029900297
DO - 10.1053/gast.1999.0029900297
M3 - Article
C2 - 10419909
AN - SCOPUS:0032806274
VL - 117
SP - 297
EP - 303
JO - Gastroenterology
JF - Gastroenterology
SN - 0016-5085
IS - 2
ER -