Duration of HIV-1 Viral Suppression on Cessation of Antiretroviral Therapy in Primary Infection Correlates with Time on Therapy

Wolfgang Stöhr, Sarah Fidler, Myra McClure, Jonathan Weber, David Cooper, Gita Ramjee, Pontiano Kaleebu, Giuseppe Tambussi, Mauro Schechter, Abdel Babiker, Rodney E. Phillips, Kholoud Porter, John Frater

Research output: Contribution to journalArticle

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Abstract

Objective:A minority of HIV-1 positive individuals treated with antiretroviral therapy (ART) in primary HIV-1 infection (PHI) maintain viral suppression on stopping. Whether this is related to ART duration has not been explored.Design:And Methods: Using SPARTAC trial data from individuals recruited within 6 months of seroconversion, we present an observational analysis investigating whether duration of ART was associated with post-treatment viraemic control. Kaplan-Meier estimates, logistic regression and Cox models were used.Results:165 participants reached plasma viral loads (VL) 12 weeks compared to ≤12 weeks (p=0.061). Cumulative probabilities of remaining 12 weeks.In multivariable regression, ART for >12 weeks was independently associated with a lower probability of being ≥400 copies/ml within 12 weeks of ART stop (OR=0.11 (95%CI=0.03,0.34), p

Original languageEnglish
Article numbere78287
JournalPLoS One
Volume8
Issue number10
DOIs
Publication statusPublished - Oct 25 2013

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Human immunodeficiency virus 1
HIV-1
therapeutics
duration
Infection
infection
Logistics
Plasmas
Logistic Models
Therapeutics
Kaplan-Meier Estimate
seroconversion
viral load
Viral Load
Proportional Hazards Models
HIV Infections

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Duration of HIV-1 Viral Suppression on Cessation of Antiretroviral Therapy in Primary Infection Correlates with Time on Therapy. / Stöhr, Wolfgang; Fidler, Sarah; McClure, Myra; Weber, Jonathan; Cooper, David; Ramjee, Gita; Kaleebu, Pontiano; Tambussi, Giuseppe; Schechter, Mauro; Babiker, Abdel; Phillips, Rodney E.; Porter, Kholoud; Frater, John.

In: PLoS One, Vol. 8, No. 10, e78287, 25.10.2013.

Research output: Contribution to journalArticle

Stöhr, W, Fidler, S, McClure, M, Weber, J, Cooper, D, Ramjee, G, Kaleebu, P, Tambussi, G, Schechter, M, Babiker, A, Phillips, RE, Porter, K & Frater, J 2013, 'Duration of HIV-1 Viral Suppression on Cessation of Antiretroviral Therapy in Primary Infection Correlates with Time on Therapy', PLoS One, vol. 8, no. 10, e78287. https://doi.org/10.1371/journal.pone.0078287
Stöhr, Wolfgang ; Fidler, Sarah ; McClure, Myra ; Weber, Jonathan ; Cooper, David ; Ramjee, Gita ; Kaleebu, Pontiano ; Tambussi, Giuseppe ; Schechter, Mauro ; Babiker, Abdel ; Phillips, Rodney E. ; Porter, Kholoud ; Frater, John. / Duration of HIV-1 Viral Suppression on Cessation of Antiretroviral Therapy in Primary Infection Correlates with Time on Therapy. In: PLoS One. 2013 ; Vol. 8, No. 10.
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