Abstract
Objective:A minority of HIV-1 positive individuals treated with antiretroviral therapy (ART) in primary HIV-1 infection (PHI) maintain viral suppression on stopping. Whether this is related to ART duration has not been explored.Design:And Methods: Using SPARTAC trial data from individuals recruited within 6 months of seroconversion, we present an observational analysis investigating whether duration of ART was associated with post-treatment viraemic control. Kaplan-Meier estimates, logistic regression and Cox models were used.Results:165 participants reached plasma viral loads (VL) 12 weeks compared to ≤12 weeks (p=0.061). Cumulative probabilities of remaining 12 weeks.In multivariable regression, ART for >12 weeks was independently associated with a lower probability of being ≥400 copies/ml within 12 weeks of ART stop (OR=0.11 (95%CI=0.03,0.34), p
| Original language | English |
|---|---|
| Article number | e78287 |
| Journal | PLoS One |
| Volume | 8 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 25 2013 |
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ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
Cite this
Duration of HIV-1 Viral Suppression on Cessation of Antiretroviral Therapy in Primary Infection Correlates with Time on Therapy. / Stöhr, Wolfgang; Fidler, Sarah; McClure, Myra; Weber, Jonathan; Cooper, David; Ramjee, Gita; Kaleebu, Pontiano; Tambussi, Giuseppe; Schechter, Mauro; Babiker, Abdel; Phillips, Rodney E.; Porter, Kholoud; Frater, John.
In: PLoS One, Vol. 8, No. 10, e78287, 25.10.2013.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Duration of HIV-1 Viral Suppression on Cessation of Antiretroviral Therapy in Primary Infection Correlates with Time on Therapy
AU - Stöhr, Wolfgang
AU - Fidler, Sarah
AU - McClure, Myra
AU - Weber, Jonathan
AU - Cooper, David
AU - Ramjee, Gita
AU - Kaleebu, Pontiano
AU - Tambussi, Giuseppe
AU - Schechter, Mauro
AU - Babiker, Abdel
AU - Phillips, Rodney E.
AU - Porter, Kholoud
AU - Frater, John
PY - 2013/10/25
Y1 - 2013/10/25
N2 - Objective:A minority of HIV-1 positive individuals treated with antiretroviral therapy (ART) in primary HIV-1 infection (PHI) maintain viral suppression on stopping. Whether this is related to ART duration has not been explored.Design:And Methods: Using SPARTAC trial data from individuals recruited within 6 months of seroconversion, we present an observational analysis investigating whether duration of ART was associated with post-treatment viraemic control. Kaplan-Meier estimates, logistic regression and Cox models were used.Results:165 participants reached plasma viral loads (VL) 12 weeks compared to ≤12 weeks (p=0.061). Cumulative probabilities of remaining 12 weeks.In multivariable regression, ART for >12 weeks was independently associated with a lower probability of being ≥400 copies/ml within 12 weeks of ART stop (OR=0.11 (95%CI=0.03,0.34), p
AB - Objective:A minority of HIV-1 positive individuals treated with antiretroviral therapy (ART) in primary HIV-1 infection (PHI) maintain viral suppression on stopping. Whether this is related to ART duration has not been explored.Design:And Methods: Using SPARTAC trial data from individuals recruited within 6 months of seroconversion, we present an observational analysis investigating whether duration of ART was associated with post-treatment viraemic control. Kaplan-Meier estimates, logistic regression and Cox models were used.Results:165 participants reached plasma viral loads (VL) 12 weeks compared to ≤12 weeks (p=0.061). Cumulative probabilities of remaining 12 weeks.In multivariable regression, ART for >12 weeks was independently associated with a lower probability of being ≥400 copies/ml within 12 weeks of ART stop (OR=0.11 (95%CI=0.03,0.34), p
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U2 - 10.1371/journal.pone.0078287
DO - 10.1371/journal.pone.0078287
M3 - Article
VL - 8
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 10
M1 - e78287
ER -