Duration of HIV-1 Viral Suppression on Cessation of Antiretroviral Therapy in Primary Infection Correlates with Time on Therapy

Wolfgang Stöhr; Sarah Fidler; Myra McClure; Jonathan Weber; David Cooper; Gita Ramjee; Pontiano Kaleebu; Giuseppe Tambussi; Mauro Schechter; Abdel Babiker; Rodney E. Phillips; Kholoud Porter; John Frater

doi:10.1371/journal.pone.0078287

Duration of HIV-1 Viral Suppression on Cessation of Antiretroviral Therapy in Primary Infection Correlates with Time on Therapy

Wolfgang Stöhr, Sarah Fidler, Myra McClure, Jonathan Weber, David Cooper, Gita Ramjee, Pontiano Kaleebu, Giuseppe Tambussi, Mauro Schechter, Abdel Babiker, Rodney E. Phillips, Kholoud Porter, John Frater

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Objective:A minority of HIV-1 positive individuals treated with antiretroviral therapy (ART) in primary HIV-1 infection (PHI) maintain viral suppression on stopping. Whether this is related to ART duration has not been explored.Design:And Methods: Using SPARTAC trial data from individuals recruited within 6 months of seroconversion, we present an observational analysis investigating whether duration of ART was associated with post-treatment viraemic control. Kaplan-Meier estimates, logistic regression and Cox models were used.Results:165 participants reached plasma viral loads (VL) 12 weeks compared to ≤12 weeks (p=0.061). Cumulative probabilities of remaining 12 weeks.In multivariable regression, ART for >12 weeks was independently associated with a lower probability of being ≥400 copies/ml within 12 weeks of ART stop (OR=0.11 (95%CI=0.03,0.34), p

Original language	English
Article number	e78287
Journal	PLoS One
Volume	8
Issue number	10
DOIs	https://doi.org/10.1371/journal.pone.0078287
Publication status	Published - Oct 25 2013

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

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Stöhr, W., Fidler, S., McClure, M., Weber, J., Cooper, D., Ramjee, G., Kaleebu, P., Tambussi, G., Schechter, M., Babiker, A., Phillips, R. E., Porter, K., & Frater, J. (2013). Duration of HIV-1 Viral Suppression on Cessation of Antiretroviral Therapy in Primary Infection Correlates with Time on Therapy. PLoS One, 8(10), [e78287]. https://doi.org/10.1371/journal.pone.0078287

Duration of HIV-1 Viral Suppression on Cessation of Antiretroviral Therapy in Primary Infection Correlates with Time on Therapy. / Stöhr, Wolfgang; Fidler, Sarah; McClure, Myra; Weber, Jonathan; Cooper, David; Ramjee, Gita; Kaleebu, Pontiano; Tambussi, Giuseppe; Schechter, Mauro; Babiker, Abdel; Phillips, Rodney E.; Porter, Kholoud; Frater, John.

In: PLoS One, Vol. 8, No. 10, e78287, 25.10.2013.

Research output: Contribution to journal › Article › peer-review

Stöhr, Wolfgang ; Fidler, Sarah ; McClure, Myra ; Weber, Jonathan ; Cooper, David ; Ramjee, Gita ; Kaleebu, Pontiano ; Tambussi, Giuseppe ; Schechter, Mauro ; Babiker, Abdel ; Phillips, Rodney E. ; Porter, Kholoud ; Frater, John. / Duration of HIV-1 Viral Suppression on Cessation of Antiretroviral Therapy in Primary Infection Correlates with Time on Therapy. In: PLoS One. 2013 ; Vol. 8, No. 10.

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