Duration of ischemia influences the development and resolution of ischemic brain edema

Nicholas V. Todd, Piero Picozzi, H. Alan Crockard, And W Ross Russell Ralph

Research output: Contribution to journalArticlepeer-review

Abstract

The influence of the duration of ischemia on the development and resolution of post-ischemic brain edema (SG method) was studied in anesthetized rats. Edema developed during ischemia and the amount of edema was related to the duration of ischemia (r = 0.843, p < 0.001). With recirculation to three hours, the major determinant of the amount of edema was still the duration of the preceding ischemia (p < 0.001). Resolution of brain edema only occurred following fifteen minutes ischemia. Post-ischemic bloodbrain barrier breakdown (14C-AIB, EB albumin) was greatest following longer ischemia. Where present, the BBB leakage was simultaneously to large and small molecules.

Original languageEnglish
Pages (from-to)466-471
Number of pages6
JournalStroke
Volume17
Issue number3
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialised Nursing
  • Neuroscience(all)

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