The influence of the duration of ischemia on the development and resolution of post-ischemic brain edema (SG method) was studied in anesthetized rats. Edema developed during ischemia and the amount of edema was related to the duration of ischemia (r = 0.843, p < 0.001). With recirculation to three hours, the major determinant of the amount of edema was still the duration of the preceding ischemia (p < 0.001). Resolution of brain edema only occurred following fifteen minutes ischemia. Post-ischemic bloodbrain barrier breakdown (14C-AIB, EB albumin) was greatest following longer ischemia. Where present, the BBB leakage was simultaneously to large and small molecules.
|Number of pages||6|
|Publication status||Published - 1986|
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Clinical Neurology
- Advanced and Specialised Nursing