Duration of red blood cell storage and outcomes in pediatric cardiac surgery: an association found for pump prime blood.

Marco Ranucci, Concetta Carlucci, Giuseppe Isgrò, Alessandra Boncilli, Donatella De Benedetti, Teresa De la Torre, Simonetta Brozzi, Alessandro Frigiola

Research output: Contribution to journalArticle

Abstract

INTRODUCTION: Cardiac surgery using cardiopulmonary bypass in newborns, infants and small children often requires intraoperative red blood cell transfusions to prime the circuit and oxygenator and to replace blood lost during surgery. The purpose of this study was to investigate the influence of red blood cell storage time prior to transfusion on postoperative morbidity in pediatric cardiac operations. METHODS: One hundred ninety-two consecutive children aged five years or less who underwent cardiac operations using cardiopulmonary bypass and who received red blood cells for priming the cardiopulmonary bypass circuit comprised the blood-prime group. Forty-seven patients receiving red blood cell transfusions after cardiopulmonary bypass were separately analyzed. Patients in the blood-prime group were divided into two groups based on the duration of storage of the red blood cells they received. The newer blood group included patients who received only red blood cells stored for less than or equal to four days and the older blood group included patients who received red blood cells stored for more than four days. RESULTS: Patients in the newer blood group had a significantly lower rate of pulmonary complications (3.5% versus 14.4%; P = 0.011) as well as a lower rate of acute renal failure (0.8% versus 5.2%; P = 0.154) than patients in the older blood group. Major complications (calculated as a composite score based on pulmonary, neurological, and gastroenterological complications, sepsis and acute renal failure) were found in 6.9% of the patients receiving newer blood and 17.1% of the patients receiving older blood (P = 0.027). After adjusting for other possible confounding variables, red blood cell storage time remained an independent predictor of major morbidity. The same association was not found for patients receiving red blood cell transfusions after cardiopulmonary bypass. CONCLUSIONS: The storage time of the red blood cells used for priming the cardiopulmonary bypass circuit in cardiac operations on newborns and young infants is an independent risk factor for major postoperative morbidity. Pulmonary complications, acute renal failure, and infections are the main complications associated with increased red blood cell storage time.

Original languageEnglish
JournalCritical Care
Volume13
Issue number6
Publication statusPublished - 2009

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Thoracic Surgery
Erythrocytes
Pediatrics
Blood Group Antigens
Cardiopulmonary Bypass
Erythrocyte Transfusion
Acute Kidney Injury
Morbidity
Lung
Newborn Infant
Oxygenators
Confounding Factors (Epidemiology)
Sepsis
Infection

ASJC Scopus subject areas

  • Medicine(all)

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Duration of red blood cell storage and outcomes in pediatric cardiac surgery : an association found for pump prime blood. / Ranucci, Marco; Carlucci, Concetta; Isgrò, Giuseppe; Boncilli, Alessandra; De Benedetti, Donatella; De la Torre, Teresa; Brozzi, Simonetta; Frigiola, Alessandro.

In: Critical Care, Vol. 13, No. 6, 2009.

Research output: Contribution to journalArticle

Ranucci, M, Carlucci, C, Isgrò, G, Boncilli, A, De Benedetti, D, De la Torre, T, Brozzi, S & Frigiola, A 2009, 'Duration of red blood cell storage and outcomes in pediatric cardiac surgery: an association found for pump prime blood.', Critical Care, vol. 13, no. 6.
Ranucci, Marco ; Carlucci, Concetta ; Isgrò, Giuseppe ; Boncilli, Alessandra ; De Benedetti, Donatella ; De la Torre, Teresa ; Brozzi, Simonetta ; Frigiola, Alessandro. / Duration of red blood cell storage and outcomes in pediatric cardiac surgery : an association found for pump prime blood. In: Critical Care. 2009 ; Vol. 13, No. 6.
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abstract = "INTRODUCTION: Cardiac surgery using cardiopulmonary bypass in newborns, infants and small children often requires intraoperative red blood cell transfusions to prime the circuit and oxygenator and to replace blood lost during surgery. The purpose of this study was to investigate the influence of red blood cell storage time prior to transfusion on postoperative morbidity in pediatric cardiac operations. METHODS: One hundred ninety-two consecutive children aged five years or less who underwent cardiac operations using cardiopulmonary bypass and who received red blood cells for priming the cardiopulmonary bypass circuit comprised the blood-prime group. Forty-seven patients receiving red blood cell transfusions after cardiopulmonary bypass were separately analyzed. Patients in the blood-prime group were divided into two groups based on the duration of storage of the red blood cells they received. The newer blood group included patients who received only red blood cells stored for less than or equal to four days and the older blood group included patients who received red blood cells stored for more than four days. RESULTS: Patients in the newer blood group had a significantly lower rate of pulmonary complications (3.5{\%} versus 14.4{\%}; P = 0.011) as well as a lower rate of acute renal failure (0.8{\%} versus 5.2{\%}; P = 0.154) than patients in the older blood group. Major complications (calculated as a composite score based on pulmonary, neurological, and gastroenterological complications, sepsis and acute renal failure) were found in 6.9{\%} of the patients receiving newer blood and 17.1{\%} of the patients receiving older blood (P = 0.027). After adjusting for other possible confounding variables, red blood cell storage time remained an independent predictor of major morbidity. The same association was not found for patients receiving red blood cell transfusions after cardiopulmonary bypass. CONCLUSIONS: The storage time of the red blood cells used for priming the cardiopulmonary bypass circuit in cardiac operations on newborns and young infants is an independent risk factor for major postoperative morbidity. Pulmonary complications, acute renal failure, and infections are the main complications associated with increased red blood cell storage time.",
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T1 - Duration of red blood cell storage and outcomes in pediatric cardiac surgery

T2 - an association found for pump prime blood.

AU - Ranucci, Marco

AU - Carlucci, Concetta

AU - Isgrò, Giuseppe

AU - Boncilli, Alessandra

AU - De Benedetti, Donatella

AU - De la Torre, Teresa

AU - Brozzi, Simonetta

AU - Frigiola, Alessandro

PY - 2009

Y1 - 2009

N2 - INTRODUCTION: Cardiac surgery using cardiopulmonary bypass in newborns, infants and small children often requires intraoperative red blood cell transfusions to prime the circuit and oxygenator and to replace blood lost during surgery. The purpose of this study was to investigate the influence of red blood cell storage time prior to transfusion on postoperative morbidity in pediatric cardiac operations. METHODS: One hundred ninety-two consecutive children aged five years or less who underwent cardiac operations using cardiopulmonary bypass and who received red blood cells for priming the cardiopulmonary bypass circuit comprised the blood-prime group. Forty-seven patients receiving red blood cell transfusions after cardiopulmonary bypass were separately analyzed. Patients in the blood-prime group were divided into two groups based on the duration of storage of the red blood cells they received. The newer blood group included patients who received only red blood cells stored for less than or equal to four days and the older blood group included patients who received red blood cells stored for more than four days. RESULTS: Patients in the newer blood group had a significantly lower rate of pulmonary complications (3.5% versus 14.4%; P = 0.011) as well as a lower rate of acute renal failure (0.8% versus 5.2%; P = 0.154) than patients in the older blood group. Major complications (calculated as a composite score based on pulmonary, neurological, and gastroenterological complications, sepsis and acute renal failure) were found in 6.9% of the patients receiving newer blood and 17.1% of the patients receiving older blood (P = 0.027). After adjusting for other possible confounding variables, red blood cell storage time remained an independent predictor of major morbidity. The same association was not found for patients receiving red blood cell transfusions after cardiopulmonary bypass. CONCLUSIONS: The storage time of the red blood cells used for priming the cardiopulmonary bypass circuit in cardiac operations on newborns and young infants is an independent risk factor for major postoperative morbidity. Pulmonary complications, acute renal failure, and infections are the main complications associated with increased red blood cell storage time.

AB - INTRODUCTION: Cardiac surgery using cardiopulmonary bypass in newborns, infants and small children often requires intraoperative red blood cell transfusions to prime the circuit and oxygenator and to replace blood lost during surgery. The purpose of this study was to investigate the influence of red blood cell storage time prior to transfusion on postoperative morbidity in pediatric cardiac operations. METHODS: One hundred ninety-two consecutive children aged five years or less who underwent cardiac operations using cardiopulmonary bypass and who received red blood cells for priming the cardiopulmonary bypass circuit comprised the blood-prime group. Forty-seven patients receiving red blood cell transfusions after cardiopulmonary bypass were separately analyzed. Patients in the blood-prime group were divided into two groups based on the duration of storage of the red blood cells they received. The newer blood group included patients who received only red blood cells stored for less than or equal to four days and the older blood group included patients who received red blood cells stored for more than four days. RESULTS: Patients in the newer blood group had a significantly lower rate of pulmonary complications (3.5% versus 14.4%; P = 0.011) as well as a lower rate of acute renal failure (0.8% versus 5.2%; P = 0.154) than patients in the older blood group. Major complications (calculated as a composite score based on pulmonary, neurological, and gastroenterological complications, sepsis and acute renal failure) were found in 6.9% of the patients receiving newer blood and 17.1% of the patients receiving older blood (P = 0.027). After adjusting for other possible confounding variables, red blood cell storage time remained an independent predictor of major morbidity. The same association was not found for patients receiving red blood cell transfusions after cardiopulmonary bypass. CONCLUSIONS: The storage time of the red blood cells used for priming the cardiopulmonary bypass circuit in cardiac operations on newborns and young infants is an independent risk factor for major postoperative morbidity. Pulmonary complications, acute renal failure, and infections are the main complications associated with increased red blood cell storage time.

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