DVHs evaluation in brain metastases stereotactic radiotherapy treatment plans

Katia Pasciuti, Giuseppe Iaccarino, Antonella Soriani, Vicente Bruzzaniti, Simona Marzi, Sara Gomellini, Stefano Arcangeli, Marcello Benassi, Valeria Landoni

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Purpose: The aim of this work is to report a retrospective study of radiobiological indicators based on Dose-Volume Histograms analysis obtained by stereotactic radiotherapy treatments. Methods and materials: Fifty-five patients for a total of sixty-seven brain metastases with a mean target volume of 8.49 cc were treated by Dynamic Conformal Arc Therapy (DCAT) and Intensity-Modulated Stereotactic Radiotherapy (IMRST). The Delivered prescription dose was chosen on the basis of tumor size and location so as to ensure a 100% isodose coverage to the target volume. Results: The treatment plans reported a mean value of 10% and 2.19% for the inhomogeneity and conformal index, respectively. The F factor showed we overdosed sixty-three patients delivering an additional 7% dose more than calculated values. The radiobiological parameters: TCP and NTCP showed a complete tumor control limiting the organs at risk damage. Conclusion: One goal of stereotactic radiotherapy is to design a treatment plan in which the steep dose gradient achievable minimizes the amount of radiation delivered outside the tumor region. This technique allows to deliver a much larger dose to the target without exceeding the radiation-related tolerance of normal tissues and improving patients' quality of life.

Original languageEnglish
Pages (from-to)110-115
Number of pages6
JournalRadiotherapy and Oncology
Volume87
Issue number1
DOIs
Publication statusPublished - Apr 2008

Fingerprint

Radiotherapy
Neoplasm Metastasis
Brain
Organs at Risk
Intensity-Modulated Radiotherapy
Neoplasms
Radiation Tolerance
Therapeutics
Prescriptions
Retrospective Studies
Quality of Life
Radiation

Keywords

  • Brain metastases
  • Dynamic conformal arcs
  • Intensity-modulated stereotactic radiotherapy
  • Stereotactic radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Urology

Cite this

DVHs evaluation in brain metastases stereotactic radiotherapy treatment plans. / Pasciuti, Katia; Iaccarino, Giuseppe; Soriani, Antonella; Bruzzaniti, Vicente; Marzi, Simona; Gomellini, Sara; Arcangeli, Stefano; Benassi, Marcello; Landoni, Valeria.

In: Radiotherapy and Oncology, Vol. 87, No. 1, 04.2008, p. 110-115.

Research output: Contribution to journalArticle

Pasciuti, K, Iaccarino, G, Soriani, A, Bruzzaniti, V, Marzi, S, Gomellini, S, Arcangeli, S, Benassi, M & Landoni, V 2008, 'DVHs evaluation in brain metastases stereotactic radiotherapy treatment plans', Radiotherapy and Oncology, vol. 87, no. 1, pp. 110-115. https://doi.org/10.1016/j.radonc.2007.12.019
Pasciuti, Katia ; Iaccarino, Giuseppe ; Soriani, Antonella ; Bruzzaniti, Vicente ; Marzi, Simona ; Gomellini, Sara ; Arcangeli, Stefano ; Benassi, Marcello ; Landoni, Valeria. / DVHs evaluation in brain metastases stereotactic radiotherapy treatment plans. In: Radiotherapy and Oncology. 2008 ; Vol. 87, No. 1. pp. 110-115.
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