Abstract
Purpose: The aim of this work is to report a retrospective study of radiobiological indicators based on Dose-Volume Histograms analysis obtained by stereotactic radiotherapy treatments. Methods and materials: Fifty-five patients for a total of sixty-seven brain metastases with a mean target volume of 8.49 cc were treated by Dynamic Conformal Arc Therapy (DCAT) and Intensity-Modulated Stereotactic Radiotherapy (IMRST). The Delivered prescription dose was chosen on the basis of tumor size and location so as to ensure a 100% isodose coverage to the target volume. Results: The treatment plans reported a mean value of 10% and 2.19% for the inhomogeneity and conformal index, respectively. The F factor showed we overdosed sixty-three patients delivering an additional 7% dose more than calculated values. The radiobiological parameters: TCP and NTCP showed a complete tumor control limiting the organs at risk damage. Conclusion: One goal of stereotactic radiotherapy is to design a treatment plan in which the steep dose gradient achievable minimizes the amount of radiation delivered outside the tumor region. This technique allows to deliver a much larger dose to the target without exceeding the radiation-related tolerance of normal tissues and improving patients' quality of life.
| Original language | English |
|---|---|
| Pages (from-to) | 110-115 |
| Number of pages | 6 |
| Journal | Radiotherapy and Oncology |
| Volume | 87 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Apr 2008 |
Fingerprint
Keywords
- Brain metastases
- Dynamic conformal arcs
- Intensity-modulated stereotactic radiotherapy
- Stereotactic radiotherapy
ASJC Scopus subject areas
- Oncology
- Radiology Nuclear Medicine and imaging
- Urology
Cite this
DVHs evaluation in brain metastases stereotactic radiotherapy treatment plans. / Pasciuti, Katia; Iaccarino, Giuseppe; Soriani, Antonella; Bruzzaniti, Vicente; Marzi, Simona; Gomellini, Sara; Arcangeli, Stefano; Benassi, Marcello; Landoni, Valeria.
In: Radiotherapy and Oncology, Vol. 87, No. 1, 04.2008, p. 110-115.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - DVHs evaluation in brain metastases stereotactic radiotherapy treatment plans
AU - Pasciuti, Katia
AU - Iaccarino, Giuseppe
AU - Soriani, Antonella
AU - Bruzzaniti, Vicente
AU - Marzi, Simona
AU - Gomellini, Sara
AU - Arcangeli, Stefano
AU - Benassi, Marcello
AU - Landoni, Valeria
PY - 2008/4
Y1 - 2008/4
N2 - Purpose: The aim of this work is to report a retrospective study of radiobiological indicators based on Dose-Volume Histograms analysis obtained by stereotactic radiotherapy treatments. Methods and materials: Fifty-five patients for a total of sixty-seven brain metastases with a mean target volume of 8.49 cc were treated by Dynamic Conformal Arc Therapy (DCAT) and Intensity-Modulated Stereotactic Radiotherapy (IMRST). The Delivered prescription dose was chosen on the basis of tumor size and location so as to ensure a 100% isodose coverage to the target volume. Results: The treatment plans reported a mean value of 10% and 2.19% for the inhomogeneity and conformal index, respectively. The F factor showed we overdosed sixty-three patients delivering an additional 7% dose more than calculated values. The radiobiological parameters: TCP and NTCP showed a complete tumor control limiting the organs at risk damage. Conclusion: One goal of stereotactic radiotherapy is to design a treatment plan in which the steep dose gradient achievable minimizes the amount of radiation delivered outside the tumor region. This technique allows to deliver a much larger dose to the target without exceeding the radiation-related tolerance of normal tissues and improving patients' quality of life.
AB - Purpose: The aim of this work is to report a retrospective study of radiobiological indicators based on Dose-Volume Histograms analysis obtained by stereotactic radiotherapy treatments. Methods and materials: Fifty-five patients for a total of sixty-seven brain metastases with a mean target volume of 8.49 cc were treated by Dynamic Conformal Arc Therapy (DCAT) and Intensity-Modulated Stereotactic Radiotherapy (IMRST). The Delivered prescription dose was chosen on the basis of tumor size and location so as to ensure a 100% isodose coverage to the target volume. Results: The treatment plans reported a mean value of 10% and 2.19% for the inhomogeneity and conformal index, respectively. The F factor showed we overdosed sixty-three patients delivering an additional 7% dose more than calculated values. The radiobiological parameters: TCP and NTCP showed a complete tumor control limiting the organs at risk damage. Conclusion: One goal of stereotactic radiotherapy is to design a treatment plan in which the steep dose gradient achievable minimizes the amount of radiation delivered outside the tumor region. This technique allows to deliver a much larger dose to the target without exceeding the radiation-related tolerance of normal tissues and improving patients' quality of life.
KW - Brain metastases
KW - Dynamic conformal arcs
KW - Intensity-modulated stereotactic radiotherapy
KW - Stereotactic radiotherapy
UR - http://www.scopus.com/inward/record.url?scp=41949112303&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=41949112303&partnerID=8YFLogxK
U2 - 10.1016/j.radonc.2007.12.019
DO - 10.1016/j.radonc.2007.12.019
M3 - Article
C2 - 18207593
AN - SCOPUS:41949112303
VL - 87
SP - 110
EP - 115
JO - Radiotherapy and Oncology
JF - Radiotherapy and Oncology
SN - 0167-8140
IS - 1
ER -