DVT Management and Outcome Trends, 2001 to 2014

Raquel Morillo, David Jiménez, Miguel Ángel Aibar, Daniela Mastroiacovo, Philip S. Wells, A. Samperiz, Marta Saraiva De Sousa, Alfonso Muriel, Roger D. Yusen, M. Monreal, M. Monreal, H. Decousus, P. Prandoni, Benjamin Brenner, R. Barba, P. Di Micco, Laurent Bertoletti, S. Schellong, I. Tzoran, A. Reis & 152 others Marijan Bosevski, H. Bounameaux, R. Malý, Philip Wells, Manolis Papadakis, P. Agudo, M. A. Aibar, M. Akasbi, M. Alcalde-Manero, V. Andújar, J. I. Arcelus, A. Ballaz, R. Barba, Manuel Barrón, B. Barrón-Andrés, J. Bascuñana, A. Blanco-Molina, I. Cañas, I. Casado, J. de Miguel, J. Del Toro, S. Díaz, J. A. Díaz Peromingo, C. Falgá, C. Fernández-Capitán, C. Font, L. Font, P. Gallego, F. García-Bragado, M. García-Rodenas, V. Gómez, C. J. González, E. Grau, L. Guirado, J. Gutiérrez, G. Hernández, L. Hernández-Blasco, V. Isern, L. Jara-Palomares, M. J. Jaras, D. Jiménez, J. L. Lobo, L. López-Jiménez, R. López-Reyes, J. B. López-Sáez, M. A. Lorente, A. Lorenzo, O. Madridano, A. Maestre, P. J. Marchena, M. Martín, J. M. Martín-Antorán, F. Martín-Martos, Manuel Monreal, M. V. Morales, D. Nauffal, J. A. Nieto, S. Nieto, M. J. Núñez, C. Orbegoso, S. Otalora, R. Otero, B. Pagán, J. M. Pedrajas, C. Pérez, G. Pérez, M. L. Peris, I. Pons, J. A. Porras, O. Reig, A. Riera-Mestre, A. Rivas, C. Rodríguez, M. A. Rodríguez-Dávila, V. Rosa, A. S. Rosa-Murillo, N. Ruiz-Giménez, J. C. Sahuquillo, M. C. Sala, A. Sampériz, R. Sánchez, O. Sanz, S. Soler, J. M. Suriñach, C. Tolosa, Javier Trujillo-Santos, F. Uresandi, B. Valero, R. Valle, J. Vela, G. Vidal, C. Vilar, J. Villalta, B. Xifre, T. Vanassche, P. Verhamme, P. S. Wells, Jana Hirmerova, R. Malý, T. Tomko, G. Celis, E. Salgado, G. T. Sánchez, L. Bertoletti, A. Bura-Riviere, Dominique Farge-Bancel, Adrian Hij, I. Mahe, A. Merah, I. Quere, M. Papadakis, A. Braester, B. Brenner, I. Tzoran, A. Apollonio, G. Barillari, A. Bertone, F. Bilora, E. Bucherini, M. Ciammaichella, P. De Ciantis, Francesco Dentali, P. Di Micco, R. Duce, P. Ferrazzi, Elvira Grandone, Gianfranco Lessiani, Corrado Lodigiani, D. Mastroiacovo, F. Pace, R. Pesavento, M. Pinelli, R. Poggio, P. Prandoni, M. Rosa, Lidia Luciana Rota, E. Tiraferri, D. Tonello, Antonella Tufano, U. Venturelli, A. Visonà, B. Zalunardo, E. Drucka, D. Kigitovica, A. Skride, A. Mafalda, J. L. Ribeiro, M. S. Sousa, M. Bosevski, M. Zdraveska, H. Bounameaux, L. Mazzolai

Research output: Contribution to journalArticle

Abstract

Background A comprehensive evaluation of temporal trends in the treatment of patients who have DVT may assist with identification of modifiable factors that contribute to short-term outcomes. Methods We assessed temporal trends in length of hospital stay and use of pharmacological and interventional therapies among 26,695 adults with DVT enrolled in the Registro Informatizado de la Enfermedad TromboEmbólica registry between 2001 and 2014. We also examined temporal trends in risk-adjusted rates of all-cause, pulmonary embolism-related, and bleeding-related death to 30 days after diagnosis. Results The mean length of hospital stay decreased from 9.0 days in 2001 to 2005 to 7.6 days in 2010 to 2014 (P <01). For initial DVT treatment, the use of low-molecular-weight heparin decreased from 98% to 90% (P <01). Direct oral anticoagulants use increased from 0.5% in 2010 to 13.4% in 2014 (P <001). Risk-adjusted rates of 30-day all-cause mortality decreased from 3.9% in 2001 to 2005 to 2.7% in 2010 to 2014 (adjusted rate ratio per year, 0.84; 95% CI, 0.74-0.96; P <01). VTE-related mortality showed a nonstatistically significant downward trend (adjusted rate ratio per year, 0.70; 95% CI, 0.44-1.10; P =13), whereas 30-day bleeding-related mortality significantly decreased from 0.5% in 2001 to 2005 to 0.1% in 2010-2014 (adjusted rate ratio per year, 0.55; 95% CI, 0.40-0.77; P < .01). Conclusions This international registry-based temporal analysis identified reductions in length of stay for adults hospitalized for DVT. The study also found a decreasing trend in adjusted rates of all-cause and bleeding-related mortality.

Original languageEnglish
Pages (from-to)374-383
Number of pages10
JournalChest
Volume150
Issue number2
DOIs
Publication statusPublished - Aug 1 2016

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Length of Stay
Mortality
Hemorrhage
Registries
Low Molecular Weight Heparin
Pulmonary Embolism
Anticoagulants
Therapeutics
Pharmacology

Keywords

  • DVT
  • prognosis
  • survival

ASJC Scopus subject areas

  • Medicine(all)
  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Morillo, R., Jiménez, D., Aibar, M. Á., Mastroiacovo, D., Wells, P. S., Samperiz, A., ... Mazzolai, L. (2016). DVT Management and Outcome Trends, 2001 to 2014. Chest, 150(2), 374-383. https://doi.org/10.1016/j.chest.2016.03.046

DVT Management and Outcome Trends, 2001 to 2014. / Morillo, Raquel; Jiménez, David; Aibar, Miguel Ángel; Mastroiacovo, Daniela; Wells, Philip S.; Samperiz, A.; Saraiva De Sousa, Marta; Muriel, Alfonso; Yusen, Roger D.; Monreal, M.; Monreal, M.; Decousus, H.; Prandoni, P.; Brenner, Benjamin; Barba, R.; Di Micco, P.; Bertoletti, Laurent; Schellong, S.; Tzoran, I.; Reis, A.; Bosevski, Marijan; Bounameaux, H.; Malý, R.; Wells, Philip; Papadakis, Manolis; Agudo, P.; Aibar, M. A.; Akasbi, M.; Alcalde-Manero, M.; Andújar, V.; Arcelus, J. I.; Ballaz, A.; Barba, R.; Barrón, Manuel; Barrón-Andrés, B.; Bascuñana, J.; Blanco-Molina, A.; Cañas, I.; Casado, I.; de Miguel, J.; Del Toro, J.; Díaz, S.; Díaz Peromingo, J. A.; Falgá, C.; Fernández-Capitán, C.; Font, C.; Font, L.; Gallego, P.; García-Bragado, F.; García-Rodenas, M.; Gómez, V.; González, C. J.; Grau, E.; Guirado, L.; Gutiérrez, J.; Hernández, G.; Hernández-Blasco, L.; Isern, V.; Jara-Palomares, L.; Jaras, M. J.; Jiménez, D.; Lobo, J. L.; López-Jiménez, L.; López-Reyes, R.; López-Sáez, J. B.; Lorente, M. A.; Lorenzo, A.; Madridano, O.; Maestre, A.; Marchena, P. J.; Martín, M.; Martín-Antorán, J. M.; Martín-Martos, F.; Monreal, Manuel; Morales, M. V.; Nauffal, D.; Nieto, J. A.; Nieto, S.; Núñez, M. J.; Orbegoso, C.; Otalora, S.; Otero, R.; Pagán, B.; Pedrajas, J. M.; Pérez, C.; Pérez, G.; Peris, M. L.; Pons, I.; Porras, J. A.; Reig, O.; Riera-Mestre, A.; Rivas, A.; Rodríguez, C.; Rodríguez-Dávila, M. A.; Rosa, V.; Rosa-Murillo, A. S.; Ruiz-Giménez, N.; Sahuquillo, J. C.; Sala, M. C.; Sampériz, A.; Sánchez, R.; Sanz, O.; Soler, S.; Suriñach, J. M.; Tolosa, C.; Trujillo-Santos, Javier; Uresandi, F.; Valero, B.; Valle, R.; Vela, J.; Vidal, G.; Vilar, C.; Villalta, J.; Xifre, B.; Vanassche, T.; Verhamme, P.; Wells, P. S.; Hirmerova, Jana; Malý, R.; Tomko, T.; Celis, G.; Salgado, E.; Sánchez, G. T.; Bertoletti, L.; Bura-Riviere, A.; Farge-Bancel, Dominique; Hij, Adrian; Mahe, I.; Merah, A.; Quere, I.; Papadakis, M.; Braester, A.; Brenner, B.; Tzoran, I.; Apollonio, A.; Barillari, G.; Bertone, A.; Bilora, F.; Bucherini, E.; Ciammaichella, M.; De Ciantis, P.; Dentali, Francesco; Di Micco, P.; Duce, R.; Ferrazzi, P.; Grandone, Elvira; Lessiani, Gianfranco; Lodigiani, Corrado; Mastroiacovo, D.; Pace, F.; Pesavento, R.; Pinelli, M.; Poggio, R.; Prandoni, P.; Rosa, M.; Rota, Lidia Luciana; Tiraferri, E.; Tonello, D.; Tufano, Antonella; Venturelli, U.; Visonà, A.; Zalunardo, B.; Drucka, E.; Kigitovica, D.; Skride, A.; Mafalda, A.; Ribeiro, J. L.; Sousa, M. S.; Bosevski, M.; Zdraveska, M.; Bounameaux, H.; Mazzolai, L.

In: Chest, Vol. 150, No. 2, 01.08.2016, p. 374-383.

Research output: Contribution to journalArticle

Morillo, R, Jiménez, D, Aibar, MÁ, Mastroiacovo, D, Wells, PS, Samperiz, A, Saraiva De Sousa, M, Muriel, A, Yusen, RD, Monreal, M, Monreal, M, Decousus, H, Prandoni, P, Brenner, B, Barba, R, Di Micco, P, Bertoletti, L, Schellong, S, Tzoran, I, Reis, A, Bosevski, M, Bounameaux, H, Malý, R, Wells, P, Papadakis, M, Agudo, P, Aibar, MA, Akasbi, M, Alcalde-Manero, M, Andújar, V, Arcelus, JI, Ballaz, A, Barba, R, Barrón, M, Barrón-Andrés, B, Bascuñana, J, Blanco-Molina, A, Cañas, I, Casado, I, de Miguel, J, Del Toro, J, Díaz, S, Díaz Peromingo, JA, Falgá, C, Fernández-Capitán, C, Font, C, Font, L, Gallego, P, García-Bragado, F, García-Rodenas, M, Gómez, V, González, CJ, Grau, E, Guirado, L, Gutiérrez, J, Hernández, G, Hernández-Blasco, L, Isern, V, Jara-Palomares, L, Jaras, MJ, Jiménez, D, Lobo, JL, López-Jiménez, L, López-Reyes, R, López-Sáez, JB, Lorente, MA, Lorenzo, A, Madridano, O, Maestre, A, Marchena, PJ, Martín, M, Martín-Antorán, JM, Martín-Martos, F, Monreal, M, Morales, MV, Nauffal, D, Nieto, JA, Nieto, S, Núñez, MJ, Orbegoso, C, Otalora, S, Otero, R, Pagán, B, Pedrajas, JM, Pérez, C, Pérez, G, Peris, ML, Pons, I, Porras, JA, Reig, O, Riera-Mestre, A, Rivas, A, Rodríguez, C, Rodríguez-Dávila, MA, Rosa, V, Rosa-Murillo, AS, Ruiz-Giménez, N, Sahuquillo, JC, Sala, MC, Sampériz, A, Sánchez, R, Sanz, O, Soler, S, Suriñach, JM, Tolosa, C, Trujillo-Santos, J, Uresandi, F, Valero, B, Valle, R, Vela, J, Vidal, G, Vilar, C, Villalta, J, Xifre, B, Vanassche, T, Verhamme, P, Wells, PS, Hirmerova, J, Malý, R, Tomko, T, Celis, G, Salgado, E, Sánchez, GT, Bertoletti, L, Bura-Riviere, A, Farge-Bancel, D, Hij, A, Mahe, I, Merah, A, Quere, I, Papadakis, M, Braester, A, Brenner, B, Tzoran, I, Apollonio, A, Barillari, G, Bertone, A, Bilora, F, Bucherini, E, Ciammaichella, M, De Ciantis, P, Dentali, F, Di Micco, P, Duce, R, Ferrazzi, P, Grandone, E, Lessiani, G, Lodigiani, C, Mastroiacovo, D, Pace, F, Pesavento, R, Pinelli, M, Poggio, R, Prandoni, P, Rosa, M, Rota, LL, Tiraferri, E, Tonello, D, Tufano, A, Venturelli, U, Visonà, A, Zalunardo, B, Drucka, E, Kigitovica, D, Skride, A, Mafalda, A, Ribeiro, JL, Sousa, MS, Bosevski, M, Zdraveska, M, Bounameaux, H & Mazzolai, L 2016, 'DVT Management and Outcome Trends, 2001 to 2014', Chest, vol. 150, no. 2, pp. 374-383. https://doi.org/10.1016/j.chest.2016.03.046
Morillo R, Jiménez D, Aibar MÁ, Mastroiacovo D, Wells PS, Samperiz A et al. DVT Management and Outcome Trends, 2001 to 2014. Chest. 2016 Aug 1;150(2):374-383. https://doi.org/10.1016/j.chest.2016.03.046
Morillo, Raquel ; Jiménez, David ; Aibar, Miguel Ángel ; Mastroiacovo, Daniela ; Wells, Philip S. ; Samperiz, A. ; Saraiva De Sousa, Marta ; Muriel, Alfonso ; Yusen, Roger D. ; Monreal, M. ; Monreal, M. ; Decousus, H. ; Prandoni, P. ; Brenner, Benjamin ; Barba, R. ; Di Micco, P. ; Bertoletti, Laurent ; Schellong, S. ; Tzoran, I. ; Reis, A. ; Bosevski, Marijan ; Bounameaux, H. ; Malý, R. ; Wells, Philip ; Papadakis, Manolis ; Agudo, P. ; Aibar, M. A. ; Akasbi, M. ; Alcalde-Manero, M. ; Andújar, V. ; Arcelus, J. I. ; Ballaz, A. ; Barba, R. ; Barrón, Manuel ; Barrón-Andrés, B. ; Bascuñana, J. ; Blanco-Molina, A. ; Cañas, I. ; Casado, I. ; de Miguel, J. ; Del Toro, J. ; Díaz, S. ; Díaz Peromingo, J. A. ; Falgá, C. ; Fernández-Capitán, C. ; Font, C. ; Font, L. ; Gallego, P. ; García-Bragado, F. ; García-Rodenas, M. ; Gómez, V. ; González, C. J. ; Grau, E. ; Guirado, L. ; Gutiérrez, J. ; Hernández, G. ; Hernández-Blasco, L. ; Isern, V. ; Jara-Palomares, L. ; Jaras, M. J. ; Jiménez, D. ; Lobo, J. L. ; López-Jiménez, L. ; López-Reyes, R. ; López-Sáez, J. B. ; Lorente, M. A. ; Lorenzo, A. ; Madridano, O. ; Maestre, A. ; Marchena, P. J. ; Martín, M. ; Martín-Antorán, J. M. ; Martín-Martos, F. ; Monreal, Manuel ; Morales, M. V. ; Nauffal, D. ; Nieto, J. A. ; Nieto, S. ; Núñez, M. J. ; Orbegoso, C. ; Otalora, S. ; Otero, R. ; Pagán, B. ; Pedrajas, J. M. ; Pérez, C. ; Pérez, G. ; Peris, M. L. ; Pons, I. ; Porras, J. A. ; Reig, O. ; Riera-Mestre, A. ; Rivas, A. ; Rodríguez, C. ; Rodríguez-Dávila, M. A. ; Rosa, V. ; Rosa-Murillo, A. S. ; Ruiz-Giménez, N. ; Sahuquillo, J. C. ; Sala, M. C. ; Sampériz, A. ; Sánchez, R. ; Sanz, O. ; Soler, S. ; Suriñach, J. M. ; Tolosa, C. ; Trujillo-Santos, Javier ; Uresandi, F. ; Valero, B. ; Valle, R. ; Vela, J. ; Vidal, G. ; Vilar, C. ; Villalta, J. ; Xifre, B. ; Vanassche, T. ; Verhamme, P. ; Wells, P. S. ; Hirmerova, Jana ; Malý, R. ; Tomko, T. ; Celis, G. ; Salgado, E. ; Sánchez, G. T. ; Bertoletti, L. ; Bura-Riviere, A. ; Farge-Bancel, Dominique ; Hij, Adrian ; Mahe, I. ; Merah, A. ; Quere, I. ; Papadakis, M. ; Braester, A. ; Brenner, B. ; Tzoran, I. ; Apollonio, A. ; Barillari, G. ; Bertone, A. ; Bilora, F. ; Bucherini, E. ; Ciammaichella, M. ; De Ciantis, P. ; Dentali, Francesco ; Di Micco, P. ; Duce, R. ; Ferrazzi, P. ; Grandone, Elvira ; Lessiani, Gianfranco ; Lodigiani, Corrado ; Mastroiacovo, D. ; Pace, F. ; Pesavento, R. ; Pinelli, M. ; Poggio, R. ; Prandoni, P. ; Rosa, M. ; Rota, Lidia Luciana ; Tiraferri, E. ; Tonello, D. ; Tufano, Antonella ; Venturelli, U. ; Visonà, A. ; Zalunardo, B. ; Drucka, E. ; Kigitovica, D. ; Skride, A. ; Mafalda, A. ; Ribeiro, J. L. ; Sousa, M. S. ; Bosevski, M. ; Zdraveska, M. ; Bounameaux, H. ; Mazzolai, L. / DVT Management and Outcome Trends, 2001 to 2014. In: Chest. 2016 ; Vol. 150, No. 2. pp. 374-383.
@article{296a867198a740ed9316f2af451192d8,
title = "DVT Management and Outcome Trends, 2001 to 2014",
abstract = "Background A comprehensive evaluation of temporal trends in the treatment of patients who have DVT may assist with identification of modifiable factors that contribute to short-term outcomes. Methods We assessed temporal trends in length of hospital stay and use of pharmacological and interventional therapies among 26,695 adults with DVT enrolled in the Registro Informatizado de la Enfermedad TromboEmb{\'o}lica registry between 2001 and 2014. We also examined temporal trends in risk-adjusted rates of all-cause, pulmonary embolism-related, and bleeding-related death to 30 days after diagnosis. Results The mean length of hospital stay decreased from 9.0 days in 2001 to 2005 to 7.6 days in 2010 to 2014 (P <01). For initial DVT treatment, the use of low-molecular-weight heparin decreased from 98{\%} to 90{\%} (P <01). Direct oral anticoagulants use increased from 0.5{\%} in 2010 to 13.4{\%} in 2014 (P <001). Risk-adjusted rates of 30-day all-cause mortality decreased from 3.9{\%} in 2001 to 2005 to 2.7{\%} in 2010 to 2014 (adjusted rate ratio per year, 0.84; 95{\%} CI, 0.74-0.96; P <01). VTE-related mortality showed a nonstatistically significant downward trend (adjusted rate ratio per year, 0.70; 95{\%} CI, 0.44-1.10; P =13), whereas 30-day bleeding-related mortality significantly decreased from 0.5{\%} in 2001 to 2005 to 0.1{\%} in 2010-2014 (adjusted rate ratio per year, 0.55; 95{\%} CI, 0.40-0.77; P < .01). Conclusions This international registry-based temporal analysis identified reductions in length of stay for adults hospitalized for DVT. The study also found a decreasing trend in adjusted rates of all-cause and bleeding-related mortality.",
keywords = "DVT, prognosis, survival",
author = "Raquel Morillo and David Jim{\'e}nez and Aibar, {Miguel {\'A}ngel} and Daniela Mastroiacovo and Wells, {Philip S.} and A. Samperiz and {Saraiva De Sousa}, Marta and Alfonso Muriel and Yusen, {Roger D.} and M. Monreal and M. Monreal and H. Decousus and P. Prandoni and Benjamin Brenner and R. Barba and {Di Micco}, P. and Laurent Bertoletti and S. Schellong and I. Tzoran and A. Reis and Marijan Bosevski and H. Bounameaux and R. Mal{\'y} and Philip Wells and Manolis Papadakis and P. Agudo and Aibar, {M. A.} and M. Akasbi and M. Alcalde-Manero and V. And{\'u}jar and Arcelus, {J. I.} and A. Ballaz and R. Barba and Manuel Barr{\'o}n and B. Barr{\'o}n-Andr{\'e}s and J. Bascu{\~n}ana and A. Blanco-Molina and I. Ca{\~n}as and I. Casado and {de Miguel}, J. and {Del Toro}, J. and S. D{\'i}az and {D{\'i}az Peromingo}, {J. A.} and C. Falg{\'a} and C. Fern{\'a}ndez-Capit{\'a}n and C. Font and L. Font and P. Gallego and F. Garc{\'i}a-Bragado and M. Garc{\'i}a-Rodenas and V. G{\'o}mez and Gonz{\'a}lez, {C. J.} and E. Grau and L. Guirado and J. Guti{\'e}rrez and G. Hern{\'a}ndez and L. Hern{\'a}ndez-Blasco and V. Isern and L. Jara-Palomares and Jaras, {M. J.} and D. Jim{\'e}nez and Lobo, {J. L.} and L. L{\'o}pez-Jim{\'e}nez and R. L{\'o}pez-Reyes and L{\'o}pez-S{\'a}ez, {J. B.} and Lorente, {M. A.} and A. Lorenzo and O. Madridano and A. Maestre and Marchena, {P. J.} and M. Mart{\'i}n and Mart{\'i}n-Antor{\'a}n, {J. M.} and F. Mart{\'i}n-Martos and Manuel Monreal and Morales, {M. V.} and D. Nauffal and Nieto, {J. A.} and S. Nieto and N{\'u}{\~n}ez, {M. J.} and C. Orbegoso and S. Otalora and R. Otero and B. Pag{\'a}n and Pedrajas, {J. M.} and C. P{\'e}rez and G. P{\'e}rez and Peris, {M. L.} and I. Pons and Porras, {J. A.} and O. Reig and A. Riera-Mestre and A. Rivas and C. Rodr{\'i}guez and Rodr{\'i}guez-D{\'a}vila, {M. A.} and V. Rosa and Rosa-Murillo, {A. S.} and N. Ruiz-Gim{\'e}nez and Sahuquillo, {J. C.} and Sala, {M. C.} and A. Samp{\'e}riz and R. S{\'a}nchez and O. Sanz and S. Soler and Suri{\~n}ach, {J. M.} and C. Tolosa and Javier Trujillo-Santos and F. Uresandi and B. Valero and R. Valle and J. Vela and G. Vidal and C. Vilar and J. Villalta and B. Xifre and T. Vanassche and P. Verhamme and Wells, {P. S.} and Jana Hirmerova and R. Mal{\'y} and T. Tomko and G. Celis and E. Salgado and S{\'a}nchez, {G. T.} and L. Bertoletti and A. Bura-Riviere and Dominique Farge-Bancel and Adrian Hij and I. Mahe and A. Merah and I. Quere and M. Papadakis and A. Braester and B. Brenner and I. Tzoran and A. Apollonio and G. Barillari and A. Bertone and F. Bilora and E. Bucherini and M. Ciammaichella and {De Ciantis}, P. and Francesco Dentali and {Di Micco}, P. and R. Duce and P. Ferrazzi and Elvira Grandone and Gianfranco Lessiani and Corrado Lodigiani and D. Mastroiacovo and F. Pace and R. Pesavento and M. Pinelli and R. Poggio and P. Prandoni and M. Rosa and Rota, {Lidia Luciana} and E. Tiraferri and D. Tonello and Antonella Tufano and U. Venturelli and A. Vison{\`a} and B. Zalunardo and E. Drucka and D. Kigitovica and A. Skride and A. Mafalda and Ribeiro, {J. L.} and Sousa, {M. S.} and M. Bosevski and M. Zdraveska and H. Bounameaux and L. Mazzolai",
year = "2016",
month = "8",
day = "1",
doi = "10.1016/j.chest.2016.03.046",
language = "English",
volume = "150",
pages = "374--383",
journal = "Chest",
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TY - JOUR

T1 - DVT Management and Outcome Trends, 2001 to 2014

AU - Morillo, Raquel

AU - Jiménez, David

AU - Aibar, Miguel Ángel

AU - Mastroiacovo, Daniela

AU - Wells, Philip S.

AU - Samperiz, A.

AU - Saraiva De Sousa, Marta

AU - Muriel, Alfonso

AU - Yusen, Roger D.

AU - Monreal, M.

AU - Monreal, M.

AU - Decousus, H.

AU - Prandoni, P.

AU - Brenner, Benjamin

AU - Barba, R.

AU - Di Micco, P.

AU - Bertoletti, Laurent

AU - Schellong, S.

AU - Tzoran, I.

AU - Reis, A.

AU - Bosevski, Marijan

AU - Bounameaux, H.

AU - Malý, R.

AU - Wells, Philip

AU - Papadakis, Manolis

AU - Agudo, P.

AU - Aibar, M. A.

AU - Akasbi, M.

AU - Alcalde-Manero, M.

AU - Andújar, V.

AU - Arcelus, J. I.

AU - Ballaz, A.

AU - Barba, R.

AU - Barrón, Manuel

AU - Barrón-Andrés, B.

AU - Bascuñana, J.

AU - Blanco-Molina, A.

AU - Cañas, I.

AU - Casado, I.

AU - de Miguel, J.

AU - Del Toro, J.

AU - Díaz, S.

AU - Díaz Peromingo, J. A.

AU - Falgá, C.

AU - Fernández-Capitán, C.

AU - Font, C.

AU - Font, L.

AU - Gallego, P.

AU - García-Bragado, F.

AU - García-Rodenas, M.

AU - Gómez, V.

AU - González, C. J.

AU - Grau, E.

AU - Guirado, L.

AU - Gutiérrez, J.

AU - Hernández, G.

AU - Hernández-Blasco, L.

AU - Isern, V.

AU - Jara-Palomares, L.

AU - Jaras, M. J.

AU - Jiménez, D.

AU - Lobo, J. L.

AU - López-Jiménez, L.

AU - López-Reyes, R.

AU - López-Sáez, J. B.

AU - Lorente, M. A.

AU - Lorenzo, A.

AU - Madridano, O.

AU - Maestre, A.

AU - Marchena, P. J.

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AU - Martín-Martos, F.

AU - Monreal, Manuel

AU - Morales, M. V.

AU - Nauffal, D.

AU - Nieto, J. A.

AU - Nieto, S.

AU - Núñez, M. J.

AU - Orbegoso, C.

AU - Otalora, S.

AU - Otero, R.

AU - Pagán, B.

AU - Pedrajas, J. M.

AU - Pérez, C.

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AU - Peris, M. L.

AU - Pons, I.

AU - Porras, J. A.

AU - Reig, O.

AU - Riera-Mestre, A.

AU - Rivas, A.

AU - Rodríguez, C.

AU - Rodríguez-Dávila, M. A.

AU - Rosa, V.

AU - Rosa-Murillo, A. S.

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AU - Sahuquillo, J. C.

AU - Sala, M. C.

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AU - Sanz, O.

AU - Soler, S.

AU - Suriñach, J. M.

AU - Tolosa, C.

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AU - Valle, R.

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AU - Xifre, B.

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AU - Wells, P. S.

AU - Hirmerova, Jana

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AU - Celis, G.

AU - Salgado, E.

AU - Sánchez, G. T.

AU - Bertoletti, L.

AU - Bura-Riviere, A.

AU - Farge-Bancel, Dominique

AU - Hij, Adrian

AU - Mahe, I.

AU - Merah, A.

AU - Quere, I.

AU - Papadakis, M.

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AU - Ciammaichella, M.

AU - De Ciantis, P.

AU - Dentali, Francesco

AU - Di Micco, P.

AU - Duce, R.

AU - Ferrazzi, P.

AU - Grandone, Elvira

AU - Lessiani, Gianfranco

AU - Lodigiani, Corrado

AU - Mastroiacovo, D.

AU - Pace, F.

AU - Pesavento, R.

AU - Pinelli, M.

AU - Poggio, R.

AU - Prandoni, P.

AU - Rosa, M.

AU - Rota, Lidia Luciana

AU - Tiraferri, E.

AU - Tonello, D.

AU - Tufano, Antonella

AU - Venturelli, U.

AU - Visonà, A.

AU - Zalunardo, B.

AU - Drucka, E.

AU - Kigitovica, D.

AU - Skride, A.

AU - Mafalda, A.

AU - Ribeiro, J. L.

AU - Sousa, M. S.

AU - Bosevski, M.

AU - Zdraveska, M.

AU - Bounameaux, H.

AU - Mazzolai, L.

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Background A comprehensive evaluation of temporal trends in the treatment of patients who have DVT may assist with identification of modifiable factors that contribute to short-term outcomes. Methods We assessed temporal trends in length of hospital stay and use of pharmacological and interventional therapies among 26,695 adults with DVT enrolled in the Registro Informatizado de la Enfermedad TromboEmbólica registry between 2001 and 2014. We also examined temporal trends in risk-adjusted rates of all-cause, pulmonary embolism-related, and bleeding-related death to 30 days after diagnosis. Results The mean length of hospital stay decreased from 9.0 days in 2001 to 2005 to 7.6 days in 2010 to 2014 (P <01). For initial DVT treatment, the use of low-molecular-weight heparin decreased from 98% to 90% (P <01). Direct oral anticoagulants use increased from 0.5% in 2010 to 13.4% in 2014 (P <001). Risk-adjusted rates of 30-day all-cause mortality decreased from 3.9% in 2001 to 2005 to 2.7% in 2010 to 2014 (adjusted rate ratio per year, 0.84; 95% CI, 0.74-0.96; P <01). VTE-related mortality showed a nonstatistically significant downward trend (adjusted rate ratio per year, 0.70; 95% CI, 0.44-1.10; P =13), whereas 30-day bleeding-related mortality significantly decreased from 0.5% in 2001 to 2005 to 0.1% in 2010-2014 (adjusted rate ratio per year, 0.55; 95% CI, 0.40-0.77; P < .01). Conclusions This international registry-based temporal analysis identified reductions in length of stay for adults hospitalized for DVT. The study also found a decreasing trend in adjusted rates of all-cause and bleeding-related mortality.

AB - Background A comprehensive evaluation of temporal trends in the treatment of patients who have DVT may assist with identification of modifiable factors that contribute to short-term outcomes. Methods We assessed temporal trends in length of hospital stay and use of pharmacological and interventional therapies among 26,695 adults with DVT enrolled in the Registro Informatizado de la Enfermedad TromboEmbólica registry between 2001 and 2014. We also examined temporal trends in risk-adjusted rates of all-cause, pulmonary embolism-related, and bleeding-related death to 30 days after diagnosis. Results The mean length of hospital stay decreased from 9.0 days in 2001 to 2005 to 7.6 days in 2010 to 2014 (P <01). For initial DVT treatment, the use of low-molecular-weight heparin decreased from 98% to 90% (P <01). Direct oral anticoagulants use increased from 0.5% in 2010 to 13.4% in 2014 (P <001). Risk-adjusted rates of 30-day all-cause mortality decreased from 3.9% in 2001 to 2005 to 2.7% in 2010 to 2014 (adjusted rate ratio per year, 0.84; 95% CI, 0.74-0.96; P <01). VTE-related mortality showed a nonstatistically significant downward trend (adjusted rate ratio per year, 0.70; 95% CI, 0.44-1.10; P =13), whereas 30-day bleeding-related mortality significantly decreased from 0.5% in 2001 to 2005 to 0.1% in 2010-2014 (adjusted rate ratio per year, 0.55; 95% CI, 0.40-0.77; P < .01). Conclusions This international registry-based temporal analysis identified reductions in length of stay for adults hospitalized for DVT. The study also found a decreasing trend in adjusted rates of all-cause and bleeding-related mortality.

KW - DVT

KW - prognosis

KW - survival

UR - http://www.scopus.com/inward/record.url?scp=84981266568&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84981266568&partnerID=8YFLogxK

U2 - 10.1016/j.chest.2016.03.046

DO - 10.1016/j.chest.2016.03.046

M3 - Article

VL - 150

SP - 374

EP - 383

JO - Chest

JF - Chest

SN - 0012-3692

IS - 2

ER -