The genetic analysis of THE natural protease inhibitors (PI) resistance of HCV genotype (GT)1 involves subtypes 1a and 1b. NS3 protease domain was sequentially analysed in 10 HIV/HCV GT1-coinfected individuals naïve to HCV treatment. Analysis at different time points showed that 2/3 GT1b patients were infected by a GT1a clade1 during follow-up. In one patient a switch from clade1 to clade2 and in one other patient a switch from clade2 to clade1 was revealed. Four out of ten patients had resistance-associated substitutions (RASs) at baseline. The dynamics of the dominant infecting subtype suggests the presence of mixed infection in some patients. © 2017 by Edimes - Edizioni Internazionali Srl. All rights reserved.
|Number of pages||3|
|Publication status||Published - 2017|
Bagaglio, S., Messina, E., Hasson, H., Merli, M., Andolina, A., Lazzarin, A., Uberti-Foppa, C., & Morsica, G. (2017). Dynamic change in the NS3 protease domain in HIV/HCVcoinfected patients naïve to anti-HCV protease inhibitors. New Microbiologica, 40(1), 53-55. http://www.scopus.com/inward/record.url?scp=85018769950&partnerID=8YFLogxK