Dynamic changes of anandamide in the cerebrospinal fluid of Parkinson's disease patients

Valerio Pisani, Vincenzo Moschella, Monica Bari, Filomena Fezza, Salvatore Galati, Giorgio Bernardi, Paolo Stanzione, Antonio Pisani, Mauro Maccarrone

Research output: Contribution to journalArticlepeer-review

Abstract

A correct balance between endocannabinoid and dopamine-dependent systems is believed to underlie physiological motor control. We measured the levels of the endocannabinoid anandamide in the cerebrospinal fluid of Parkinson's disease (PD) patients. Subjects were divided into three groups: newly diagnosed de novo patients, subjects undergoing drug withdrawal, and patients under pharmacological therapy. These groups were compared to age-matched control subjects. Anandamide levels in untreated patients were more than doubled as compared to controls. However, chronic dopaminergic replacement restored control anandamide levels. Abnormal anandamide increase might reflect a compensatory mechanism occurring in course of PD, aimed at normalizing dopamine depletion.

Original languageEnglish
Pages (from-to)920-924
Number of pages5
JournalMovement Disorders
Volume25
Issue number7
DOIs
Publication statusPublished - May 15 2010

Keywords

  • Anandamide
  • Cerebrospinal fluid
  • Endocannabinoid
  • Levodopa
  • Parkinson's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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