Abstract
Cortical processing of sensory stimuli typically recruits multiple areas, but how each area dynamically incorporates activity from other areas is not well understood. We investigated interactions between cortical columns of bilateral primary sensory regions (S1s) in rats by recording local field potentials and multi-unit activity simultaneously in both S1s with electrodes positioned at each cortical layer. Using dynamic connectivity analysis based on Granger-causal modeling, we found that, shortly after whisker stimulation (<10 ms), contralateral S1 (cS1) already relays activity to granular and infragranular layers of S1 in the other hemisphere, after which cS1 shows a pattern of within-column interactions that directs activity upwards toward superficial layers. This pattern of predominant upward driving was also observed in S1 ipsilateral to stimulation, but at longer latencies. In addition, we found that interactions between the two S1s most strongly target granular and infragranular layers. Taken together, the results suggest a possible mechanism for how cortical columns integrate local and large-scale neocortical computation by relaying information from deeper layers to local processing in superficial layers.
| Original language | English |
|---|---|
| Pages (from-to) | 3215-3223 |
| Number of pages | 9 |
| Journal | European Journal of Neuroscience |
| Volume | 40 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Oct 1 2014 |
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Keywords
- Barrel cortex
- Cortical column
- Functional connectivity
- Granger causality
ASJC Scopus subject areas
- Neuroscience(all)
- Medicine(all)
Cite this
Dynamic connectivity among cortical layers in local and large-scale sensory processing. / Plomp, Gijs; Quairiaux, Charles; Kiss, Jozsef Z.; Astolfi, Laura; Michel, Christoph M.
In: European Journal of Neuroscience, Vol. 40, No. 8, 01.10.2014, p. 3215-3223.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dynamic connectivity among cortical layers in local and large-scale sensory processing
AU - Plomp, Gijs
AU - Quairiaux, Charles
AU - Kiss, Jozsef Z.
AU - Astolfi, Laura
AU - Michel, Christoph M.
PY - 2014/10/1
Y1 - 2014/10/1
N2 - Cortical processing of sensory stimuli typically recruits multiple areas, but how each area dynamically incorporates activity from other areas is not well understood. We investigated interactions between cortical columns of bilateral primary sensory regions (S1s) in rats by recording local field potentials and multi-unit activity simultaneously in both S1s with electrodes positioned at each cortical layer. Using dynamic connectivity analysis based on Granger-causal modeling, we found that, shortly after whisker stimulation (<10 ms), contralateral S1 (cS1) already relays activity to granular and infragranular layers of S1 in the other hemisphere, after which cS1 shows a pattern of within-column interactions that directs activity upwards toward superficial layers. This pattern of predominant upward driving was also observed in S1 ipsilateral to stimulation, but at longer latencies. In addition, we found that interactions between the two S1s most strongly target granular and infragranular layers. Taken together, the results suggest a possible mechanism for how cortical columns integrate local and large-scale neocortical computation by relaying information from deeper layers to local processing in superficial layers.
AB - Cortical processing of sensory stimuli typically recruits multiple areas, but how each area dynamically incorporates activity from other areas is not well understood. We investigated interactions between cortical columns of bilateral primary sensory regions (S1s) in rats by recording local field potentials and multi-unit activity simultaneously in both S1s with electrodes positioned at each cortical layer. Using dynamic connectivity analysis based on Granger-causal modeling, we found that, shortly after whisker stimulation (<10 ms), contralateral S1 (cS1) already relays activity to granular and infragranular layers of S1 in the other hemisphere, after which cS1 shows a pattern of within-column interactions that directs activity upwards toward superficial layers. This pattern of predominant upward driving was also observed in S1 ipsilateral to stimulation, but at longer latencies. In addition, we found that interactions between the two S1s most strongly target granular and infragranular layers. Taken together, the results suggest a possible mechanism for how cortical columns integrate local and large-scale neocortical computation by relaying information from deeper layers to local processing in superficial layers.
KW - Barrel cortex
KW - Cortical column
KW - Functional connectivity
KW - Granger causality
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U2 - 10.1111/ejn.12687
DO - 10.1111/ejn.12687
M3 - Article
C2 - 25145779
AN - SCOPUS:84910666946
VL - 40
SP - 3215
EP - 3223
JO - European Journal of Neuroscience
JF - European Journal of Neuroscience
SN - 0953-816X
IS - 8
ER -