Dynamic Contrast Enhanced Magnetic Resonance Imaging in Monitoring Bone Metastases in Breast Cancer Patients Receiving Bisphosphonates and Endocrine Therapy

Research output: Contribution to journalArticle

Abstract

Purpose: To study the role of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) in monitoring the response of bone metastases to endocrine therapy combined with bisphosphonates in patients with breast cancer. Material and Methods: Ten breast cancer patients with bone metastases who were to receive endocrine therapy and bisphosphonates were investigated prospectively by DCE-MRI. We chose a reference lesion for each patient who was studied at baseline, within 3 weeks from the second administration of bisphosphonates, and after 4 and 8 months from the initiation of medical treatment. Time/intensity curves, representing temporal changes of signal intensity in areas of interest in the context of the target lesions (ROI), were obtained for each DCE-MRI. Results: Changes in the shape of the T/I curves suggesting tumor regression were seen shortly after the initiation of medical treatment in the three patients who had the most durable responses. Conclusion: DCE-MRI has the potential to detect early changes related to medical treatment in bone metastases from breast cancer. If confirmed in larger series, these data identify DCE-MRI as a diagnostic tool for evaluating new bone targeting antineoplastic agents.

Original languageEnglish
Pages (from-to)71-74
Number of pages4
JournalActa Radiologica
Volume45
Issue number1
Publication statusPublished - Feb 2004

Keywords

  • Bisphosphonates
  • Bone metastases
  • Breast neoplasms
  • Endocrine therapy
  • MR imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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