Dynamic contrast-enhanced magnetic resonance imaging in the early evaluation of anti-angiogenic therapy in metastatic renal cell carcinoma

Valeria Panebianco, Roberto Iacovelli, Flavio Barchetti, Amelia Altavilla, Valerio Forte, Alessandro Sciarra, Enrico Cortesi, Carlo Catalano

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: To evaluate the efficacy of dynamic contrast-enhanced magnetic resonance (DCE-MR) in the response to anti-angiogenic-targeted agents in patients with metastatic renal cell cancer (mRCC). Patients and Methods: Twenty-eight consecutive patients with sub-diaphragmatic metastases from mRCC were included in the protocol after signed informed consent. Baseline characteristics were collected and patients were first evaluated with a baseline computed tomography (CT) and DCE-MR, subsequently with a new DCE-MRI after 28 days of therapy and followed-up with CT until progression. Treatments were administered at standard doses. The changes of peak enhancement (ΔPE) and of the sum of longest tumor diameters (ΔLTD) were related to progression-free survival (PFS) and overall survival (OS). Results: The median PFS was 11.4 months [95% Confidence Interval (CI): 7.9-14.7 months) and the parametric two-tailed Pearson ' s test showed a positive correlation between the median ΔPE and the median PFS (rp=0.809; p=0.015); no significant correlation was found between the median ΔLTD and the median PFS (rp=-0.446; p=0.27). The median OS was 23.3 months (95% CI: 13.6-33.0 months) and no significant correlation was found with the median ΔPE (rp=0.218; p=0.60) or with the median ΔLTD (rp=0.012; p=0.98). Conclusion: The ΔPE but not the ΔLTD was found to be significantly related to PFS; these preliminary results suggest extending the number of patients and investigating the possible relationship with other tumor characteristics and MRI parameters.

Original languageEnglish
Pages (from-to)5663-5666
Number of pages4
JournalAnticancer Research
Volume33
Issue number12
Publication statusPublished - Dec 2013

Keywords

  • Angiogenesis
  • Metastatic renal cell carcinoma
  • MRI
  • Peak enhancement
  • Targeted therapies

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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