Dynamic contrast-enhanced ultrasonography (D-CEUS) for the early prediction of bevacizumab efficacy in patients with metastatic colorectal cancer

Michele Amadori, Domenico Barone, Emanuela Scarpi, Devil Oboldi, Elena Amadori, Gianfranco Bandi, Alice Rossi, Fabio Ferroni, Angela Ragazzini, Andrea Casadei Gardini, Giovanni Luca Frassineti, Giampaolo Gavelli, Alessandro Passardi

Research output: Contribution to journalArticle

Abstract

Objectives: To investigate early changes in tumour perfusion parameters by dynamic contrast-enhanced ultrasonography (D-CEUS) and to identify any correlation with survival and tumour response in patients with metastatic colorectal cancer (CRC) treated with bevacizumab (B). Methods: Thirty-seven patients randomized to either chemotherapy (C) plus B or C alone were considered for this study. D-CEUS was performed at baseline and after the first treatment cycle (day 15). Four D-CEUS perfusion parameters were considered: derived peak intensity (DPI), area under the curve (AUC), slope of wash-in (A) and time to peak intensity (TPI). Results: In patients treated with C plus B, a ≥22.5 % reduction in DPI, ≥20 % increase in TPI and ≥10 % reduction in AUC were correlated with higher progression-free survival in the C+B arm (p = 0.048, 0.024 and 0.010, respectively) but not in the C arm. None of the evaluated parameter modifications had a correlation with tumour response or overall survival. Conclusions: D-CEUS could be useful for detecting and quantifying dynamic changes in tumour vascularity as early as 15 days after the start of B-based therapy. Although these changes may be predictive of progression-free survival, no correlation with response or overall survival was found. Key Points: • D-CEUS showed early changes in liver metastasis perfusion in colorectal cancer. • A decrease in tumour perfusion was associated with longer progression-free survival. • The decrease in perfusion was not correlated with higher overall survival.

Original languageEnglish
Pages (from-to)2969-2978
Number of pages10
JournalEuropean Radiology
Volume28
Issue number7
DOIs
Publication statusPublished - Jul 1 2018

Keywords

  • Bevacizumab
  • Dynamic contrast-enhanced ultrasonography
  • Early prediction
  • Metastatic colorectal cancer
  • Tumour angiogenesis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Dynamic contrast-enhanced ultrasonography (D-CEUS) for the early prediction of bevacizumab efficacy in patients with metastatic colorectal cancer'. Together they form a unique fingerprint.

  • Cite this