Dynamic evaluation by TV-pupillometry of the mydriatic effect of ibopamine solution. Controlled studies

G. Micieli, C. Tassorelli, R. Iannacchero, E. Lodola, P. Barbieri, G. Nappi

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of the study was to evaluate in man the dose-effect relationship of ibopamine solution 0.25%, 0.50%, and 1% on the pupillary diameter and the pupillary reflex to light stimulus and near vision. A cross-over study was performed in comparison with a placebo and with tropicamide solution 1% in 18 healthy volunteers. The results show that ibopamine 1% determines a marked mydriatic effect. At the doses used, it produces maximum increase of the pupillary diameter with a dose-effect relationship which does not depart significantly from a straight line. The maximum mydriatic effect of ibopamine 1% is significantly greater than that of tropicamide 1%. The mydriatic effect of ibopamine lasts for about 3 h; that of tropicamide lasts longer. Tropicamide 1% markedly and for a long period inhibits the pupillary reflex both to light and to near vision. The effect of ibopamine 1% on the pupillary reflext to near vision is slight, while on the reflex to light stimulus it is essentially comparable to that of tropicamide.

Original languageEnglish
Pages (from-to)150-156
Number of pages7
JournalArzneimittel-Forschung/Drug Research
Volume40
Issue number2
Publication statusPublished - 1990

Keywords

  • Dopaminergic drugs
  • Ibopamine, clinical studies
  • Mydriatics
  • Ophthalmics
  • Tropicamide, clinical studies

ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

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