Abstract
The aim of the study was to evaluate in man the dose-effect relationship of ibopamine solution 0.25%, 0.50%, and 1% on the pupillary diameter and the pupillary reflex to light stimulus and near vision. A cross-over study was performed in comparison with a placebo and with tropicamide solution 1% in 18 healthy volunteers. The results show that ibopamine 1% determines a marked mydriatic effect. At the doses used, it produces maximum increase of the pupillary diameter with a dose-effect relationship which does not depart significantly from a straight line. The maximum mydriatic effect of ibopamine 1% is significantly greater than that of tropicamide 1%. The mydriatic effect of ibopamine lasts for about 3 h; that of tropicamide lasts longer. Tropicamide 1% markedly and for a long period inhibits the pupillary reflex both to light and to near vision. The effect of ibopamine 1% on the pupillary reflext to near vision is slight, while on the reflex to light stimulus it is essentially comparable to that of tropicamide.
| Original language | English |
|---|---|
| Pages (from-to) | 150-156 |
| Number of pages | 7 |
| Journal | Arzneimittel-Forschung/Drug Research |
| Volume | 40 |
| Issue number | 2 |
| Publication status | Published - 1990 |
Keywords
- Dopaminergic drugs
- Ibopamine, clinical studies
- Mydriatics
- Ophthalmics
- Tropicamide, clinical studies
ASJC Scopus subject areas
- Chemistry(all)
- Organic Chemistry
- Drug Discovery
- Pharmacology