Dynamic induction of the long pentraxin PTX3 in the CNS after limbic seizures: Evidence for a protective role in seizure-induced neurodegeneration

T. Ravizza, D. Moneta, B. Bottazzi, G. Peri, C. Garlanda, E. Hirsch, G. J. Richards, A. Mantovani, A. Vezzani

Research output: Contribution to journalArticle

Abstract

Pentraxin 3, a prototypic long pentraxin, is induced by proinflammatory signals in the brain. Inflammatory cytokines are rapidly induced in glia by epileptic activity. We show that pentraxin 3 immunoreactivity and mRNA are enhanced in the rat forebrain above undetectable control levels by limbic seizures with a dual pattern of induction. Within 6 h from seizure onset, pentraxin 3 immunoreactivity was increased in astrocytes. Eighteen to 48 h later, specific neuronal populations and leucocytes were strongly immunoreactive only in areas of neurodegeneration. This staining was abolished when neuronal cell loss, but not seizures, was prevented by blocking N-methyl-D-aspartate receptors. Pentraxin 3 -/- mice had a more widespread seizure-related neuronal damage in the forebrain than their wild-type littermates although both groups had similar epileptic activity. Our results provide evidence that pentraxin 3 is synthesized in brain after seizures and may exert a protective role in seizure-induced neurodegeneration.

Original languageEnglish
Pages (from-to)43-53
Number of pages11
JournalNeuroscience
Volume105
Issue number1
DOIs
Publication statusPublished - Jul 16 2001

Keywords

  • Acute phase proteins
  • Cytokines
  • Epilepsy
  • Kainic acid
  • Limbic system
  • Pentraxins

ASJC Scopus subject areas

  • Neuroscience(all)

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