Dynamic measurement of newly formed carbonyl compounds in vapors from electronic cigarettes

Cecilia Sala, Claudio Medana, Raffaele Pellegrino, Riccardo Aigotti, Federica Dal Bello, Giancarlo Bianchi, Enrico Davoli

Research output: Contribution to journalArticlepeer-review


Recently, the formation of carbonyl compound within e-cigarettes usage has been reported. The aim of this study was to develop a new analytical method for the direct analysis of carbonyl compounds in vaporized liquids. Two different types of e-cigarettes and different puff’s duration have been evaluated, using a modified smoking machine for vapor generation. An isotopic dilution approach, based on deuterated internal standard addition to the e-liquid before filling the e-cigarette tank, has been developed. Carbonyl compounds have been sampled in vapors using a direct, simple, solid-phase microextraction technique with on-fiber derivatization. Related oximes have been analyzed by gas chromatography/mass spectrometry technique. Results confirmed that new carbonyl compounds are formed during the vaping process, and that formation depends both from the heating device and from puffing topography.

Original languageEnglish
Pages (from-to)64-69
Number of pages6
JournalEuropean Journal of Mass Spectrometry
Issue number2
Publication statusPublished - Jan 1 2017


  • Acrolein
  • E-cigarettes
  • Smoking machine

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Spectroscopy


Dive into the research topics of 'Dynamic measurement of newly formed carbonyl compounds in vapors from electronic cigarettes'. Together they form a unique fingerprint.

Cite this