Dynamic modulation of baroreflex sensitivity in health and disease

Research output: Contribution to journalArticlepeer-review


Assessment of arterial baroreflex function in humans through laboratory tests has provided a great deal of information of pathophysiological and clinical relevance. Indeed, the sensitivity of the baroreceptor-heart rate reflex quantified through these laboratory methods was shown to predict the risk of cardiovascular events and death from myocardial infarction, heart failure, and in diabetic patients. This traditional approach, however, does not provide information on daily life baroreflex cardiovascular control. Modern techniques; based on computer analysis of spontaneous blood pressure and heart rate fluctuations, are now available and allow baroreflex sensitivity to be assessed under real-life conditions with no need for external stimulation. In particular, these methods offer the possibility of investigating the dynamic modulation of baroreflex sensitivity occurring either on a minute-to-minute basis or over 24 hours.

Original languageEnglish
Pages (from-to)469-487
Number of pages19
JournalAnnals of the New York Academy of Sciences
Publication statusPublished - 2001


  • Acute myocardial infarction
  • Arterial baroreflex
  • Blood pressure variability
  • Essential hypertension
  • Heart rate variability
  • Sequence technique
  • Spectral analysis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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