Dynamic modules and heterogeneity of function: A lesson from tyrosine kinase receptors in endothelial cells

Federico Bussolino, Guido Serini, Stefania Mitola, Gianfranco Bazzoni, Elisabetta Dejana

Research output: Contribution to journalArticle

Abstract

An important unresolved issue related to tyrosine kinase receptor signaling pathways is the lack of specificity of the molecular effectors involved. The specificity of the biological responses that are nevertheless elicited may be explained by differences in activation thresholds, as well as by temporal (transient versus sustained) and topographical aspects of receptor activation. On the basis of recent lessons from endothelial cells, we argue that an additional strategy can be adopted to generate specificity, i.e. tyrosine kinase receptors may form distinct signaling modules with other transmembrane proteins, such as adhesive receptors, to elicit different biological programs in stimulated cells.

Original languageEnglish
Pages (from-to)763-767
Number of pages5
JournalEMBO Reports
Volume2
Issue number9
DOIs
Publication statusPublished - 2001

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ASJC Scopus subject areas

  • Genetics
  • Cell Biology

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