Dynamic multidimensional imaging of the human left atrial appendage

Joan M. Lacomis, Orly Goitein, Christopher Deible, Pauline L. Moran, Giuseppe Mamone, Shobhit Madan, David Schwartzman

Research output: Contribution to journalArticlepeer-review

Abstract

Aims: The human left atrial appendage (LAA) is a region of increasing interest as a target for intervention. We sought to improve insight into the anatomy of this region using computed tomography (CT). Methods and results: Multidimensional cardiac reconstruction (whole heart and isolated left atrium) from CT images was performed in each of three groups: (i) patients without atrial fibrillation (AF, n =10); (ii) patients with intermittent (paroxysmal) AF (n = 25); (iii) patients with continuous (persistent) AF (n = 10). Indices included LAA morphology, anatomical relationships, dimensions, angulation, and motility. There was substantial interindividual variation in each index. LAA morphologic differences were associated with variations in anatomical relationships. LAA dimensions in AF patients exceeded those in patients without AF, but angulation and motility were similar. The LAA could be subdivided into proximal and distal portions, each of which had distinct morphology and anatomical relationships. Dimensions in men tended to exceed those in women. Conclusion: Regardless of AF history, there is broad variation in LAA morphology, anatomical relationships, dimensions, angulation, and motility. These observations may have importance for the development of technologies for therapy delivery in this region.

Original languageEnglish
Pages (from-to)1134-1140
Number of pages7
JournalEuropace
Volume9
Issue number12
DOIs
Publication statusPublished - Dec 2007

Keywords

  • Atrial appendage
  • Atrial fibrillation
  • Computed tomography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

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