Dynamics and phylogenetic relationships of HIV-1 transmitted drug resistance according to subtype in Italy over the years 2000-14

Lavinia Fabeni, C. Alteri, D. Di Carlo, N. Orchi, L. Carioti, A. Bertoli, C. Gori, F. Forbici, F. Continenza, G. Maffongelli, C. Pinnetti, A. Vergori, A. Mondi, A. Ammassari, V. Borghi, M. Giuliani, Gabriella De Carli, S. Pittalis, S. Grisetti, A. CristaudoE. Girardi, A. Antinori, C. F. Perno, M. M. Santoro, E. Girardi, M. R. Capobianchi, C. F. Perno, N. Orchi, A. Navarra, A. Palummieri, I. Abbate, A. Ammassari, R. D'Arrigo, Gabriella De Carli, F. M. Fusco, C. Gori, S. Grisetti, A. Mariano, E. Nicastri, C. Pinnetti, S. Pittalis, V. Puro, A. Sampaolesi, M. R. Sciarrone, P. Scognamiglio, M. Selleri, C. Sias, M. Zaccarelli, A. Di Carlo, M. Giuliani, on behalf of the SENDIH Study Group

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6 Citations (Scopus)

Abstract

Background Transmitted drug-resistance (TDR) remains a critical aspect for the management of HIV-1-infected individuals. Thus, studying the dynamics of TDR is crucial to optimize HIV care. Methods In total, 4323 HIV-1 protease/reverse-transcriptase sequences from drug-naive individuals diagnosed in north and central Italy between 2000 and 2014 were analysed. TDR was evaluated over time. Maximum-likelihood and Bayesian phylogenetic trees with bootstrap and Bayesian-probability supports defined transmission clusters. Results Most individuals were males (80.2%) and Italian (72.1%), with a median (IQR) age of 37 (30-45) years. MSM accounted for 42.2% of cases, followed by heterosexuals (36.4%). Non-B subtype infections accounted for 30.8% of the overall population and increased over time (<2005-14: 19.5%-38.5%, P < 0.0001), particularly among Italians (<2005-14: 6.5%-28.8%, P < 0.0001). TDR prevalence was 8.8% and increased over time in non-B subtypes (<2005-14: 2%-7.1%, P = 0.018). Overall, 467 transmission clusters (involving 1207 individuals; 27.9%) were identified. The prevalence of individuals grouping in transmission clusters increased over time in both B (<2005-14: 12.9%-33.5%, P = 0.001) and non-B subtypes (<2005-14: 18.4%-41.9%, P = 0.006). TDR transmission clusters were 13.3% within the overall cluster observed and dramatically increased in recent years (<2005-14: 14.3%-35.5%, P = 0.005). This recent increase was mainly due to non-B subtype-infected individuals, who were also more frequently involved in large transmission clusters than those infected with a B subtype [median number of individuals in transmission clusters: 7 (IQR 6-19) versus 4 (3-4), P = 0.047]. Conclusions The epidemiology of HIV transmission changed greatly over time; the increasing number of transmission clusters (sometimes with drug resistance) shows that detection and proper treatment of the multi-transmitters is a major target for controlling HIV spread.

Original languageEnglish
Pages (from-to)2837-2845
Number of pages9
JournalJournal of Antimicrobial Chemotherapy
Volume72
Issue number10
DOIs
Publication statusPublished - Oct 1 2017

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Drug Resistance
Italy
HIV-1
HIV
Heterosexuality
Epidemiology
Infection
Pharmaceutical Preparations
Population

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

@article{65398b523af64c11b436ec2eaaaa171c,
title = "Dynamics and phylogenetic relationships of HIV-1 transmitted drug resistance according to subtype in Italy over the years 2000-14",
abstract = "Background Transmitted drug-resistance (TDR) remains a critical aspect for the management of HIV-1-infected individuals. Thus, studying the dynamics of TDR is crucial to optimize HIV care. Methods In total, 4323 HIV-1 protease/reverse-transcriptase sequences from drug-naive individuals diagnosed in north and central Italy between 2000 and 2014 were analysed. TDR was evaluated over time. Maximum-likelihood and Bayesian phylogenetic trees with bootstrap and Bayesian-probability supports defined transmission clusters. Results Most individuals were males (80.2{\%}) and Italian (72.1{\%}), with a median (IQR) age of 37 (30-45) years. MSM accounted for 42.2{\%} of cases, followed by heterosexuals (36.4{\%}). Non-B subtype infections accounted for 30.8{\%} of the overall population and increased over time (<2005-14: 19.5{\%}-38.5{\%}, P < 0.0001), particularly among Italians (<2005-14: 6.5{\%}-28.8{\%}, P < 0.0001). TDR prevalence was 8.8{\%} and increased over time in non-B subtypes (<2005-14: 2{\%}-7.1{\%}, P = 0.018). Overall, 467 transmission clusters (involving 1207 individuals; 27.9{\%}) were identified. The prevalence of individuals grouping in transmission clusters increased over time in both B (<2005-14: 12.9{\%}-33.5{\%}, P = 0.001) and non-B subtypes (<2005-14: 18.4{\%}-41.9{\%}, P = 0.006). TDR transmission clusters were 13.3{\%} within the overall cluster observed and dramatically increased in recent years (<2005-14: 14.3{\%}-35.5{\%}, P = 0.005). This recent increase was mainly due to non-B subtype-infected individuals, who were also more frequently involved in large transmission clusters than those infected with a B subtype [median number of individuals in transmission clusters: 7 (IQR 6-19) versus 4 (3-4), P = 0.047]. Conclusions The epidemiology of HIV transmission changed greatly over time; the increasing number of transmission clusters (sometimes with drug resistance) shows that detection and proper treatment of the multi-transmitters is a major target for controlling HIV spread.",
author = "Lavinia Fabeni and C. Alteri and {Di Carlo}, D. and N. Orchi and L. Carioti and A. Bertoli and C. Gori and F. Forbici and F. Continenza and G. Maffongelli and C. Pinnetti and A. Vergori and A. Mondi and A. Ammassari and V. Borghi and M. Giuliani and {De Carli}, Gabriella and S. Pittalis and S. Grisetti and A. Cristaudo and E. Girardi and A. Antinori and Perno, {C. F.} and Santoro, {M. M.} and E. Girardi and Capobianchi, {M. R.} and Perno, {C. F.} and N. Orchi and A. Navarra and A. Palummieri and I. Abbate and A. Ammassari and R. D'Arrigo and {De Carli}, Gabriella and Fusco, {F. M.} and C. Gori and S. Grisetti and A. Mariano and E. Nicastri and C. Pinnetti and S. Pittalis and V. Puro and A. Sampaolesi and Sciarrone, {M. R.} and P. Scognamiglio and M. Selleri and C. Sias and M. Zaccarelli and {Di Carlo}, A. and M. Giuliani and {on behalf of the SENDIH Study Group}",
year = "2017",
month = "10",
day = "1",
doi = "10.1093/jac/dkx231",
language = "English",
volume = "72",
pages = "2837--2845",
journal = "Journal of Antimicrobial Chemotherapy",
issn = "0305-7453",
publisher = "Oxford University Press",
number = "10",

}

TY - JOUR

T1 - Dynamics and phylogenetic relationships of HIV-1 transmitted drug resistance according to subtype in Italy over the years 2000-14

AU - Fabeni, Lavinia

AU - Alteri, C.

AU - Di Carlo, D.

AU - Orchi, N.

AU - Carioti, L.

AU - Bertoli, A.

AU - Gori, C.

AU - Forbici, F.

AU - Continenza, F.

AU - Maffongelli, G.

AU - Pinnetti, C.

AU - Vergori, A.

AU - Mondi, A.

AU - Ammassari, A.

AU - Borghi, V.

AU - Giuliani, M.

AU - De Carli, Gabriella

AU - Pittalis, S.

AU - Grisetti, S.

AU - Cristaudo, A.

AU - Girardi, E.

AU - Antinori, A.

AU - Perno, C. F.

AU - Santoro, M. M.

AU - Girardi, E.

AU - Capobianchi, M. R.

AU - Perno, C. F.

AU - Orchi, N.

AU - Navarra, A.

AU - Palummieri, A.

AU - Abbate, I.

AU - Ammassari, A.

AU - D'Arrigo, R.

AU - De Carli, Gabriella

AU - Fusco, F. M.

AU - Gori, C.

AU - Grisetti, S.

AU - Mariano, A.

AU - Nicastri, E.

AU - Pinnetti, C.

AU - Pittalis, S.

AU - Puro, V.

AU - Sampaolesi, A.

AU - Sciarrone, M. R.

AU - Scognamiglio, P.

AU - Selleri, M.

AU - Sias, C.

AU - Zaccarelli, M.

AU - Di Carlo, A.

AU - Giuliani, M.

AU - on behalf of the SENDIH Study Group

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Background Transmitted drug-resistance (TDR) remains a critical aspect for the management of HIV-1-infected individuals. Thus, studying the dynamics of TDR is crucial to optimize HIV care. Methods In total, 4323 HIV-1 protease/reverse-transcriptase sequences from drug-naive individuals diagnosed in north and central Italy between 2000 and 2014 were analysed. TDR was evaluated over time. Maximum-likelihood and Bayesian phylogenetic trees with bootstrap and Bayesian-probability supports defined transmission clusters. Results Most individuals were males (80.2%) and Italian (72.1%), with a median (IQR) age of 37 (30-45) years. MSM accounted for 42.2% of cases, followed by heterosexuals (36.4%). Non-B subtype infections accounted for 30.8% of the overall population and increased over time (<2005-14: 19.5%-38.5%, P < 0.0001), particularly among Italians (<2005-14: 6.5%-28.8%, P < 0.0001). TDR prevalence was 8.8% and increased over time in non-B subtypes (<2005-14: 2%-7.1%, P = 0.018). Overall, 467 transmission clusters (involving 1207 individuals; 27.9%) were identified. The prevalence of individuals grouping in transmission clusters increased over time in both B (<2005-14: 12.9%-33.5%, P = 0.001) and non-B subtypes (<2005-14: 18.4%-41.9%, P = 0.006). TDR transmission clusters were 13.3% within the overall cluster observed and dramatically increased in recent years (<2005-14: 14.3%-35.5%, P = 0.005). This recent increase was mainly due to non-B subtype-infected individuals, who were also more frequently involved in large transmission clusters than those infected with a B subtype [median number of individuals in transmission clusters: 7 (IQR 6-19) versus 4 (3-4), P = 0.047]. Conclusions The epidemiology of HIV transmission changed greatly over time; the increasing number of transmission clusters (sometimes with drug resistance) shows that detection and proper treatment of the multi-transmitters is a major target for controlling HIV spread.

AB - Background Transmitted drug-resistance (TDR) remains a critical aspect for the management of HIV-1-infected individuals. Thus, studying the dynamics of TDR is crucial to optimize HIV care. Methods In total, 4323 HIV-1 protease/reverse-transcriptase sequences from drug-naive individuals diagnosed in north and central Italy between 2000 and 2014 were analysed. TDR was evaluated over time. Maximum-likelihood and Bayesian phylogenetic trees with bootstrap and Bayesian-probability supports defined transmission clusters. Results Most individuals were males (80.2%) and Italian (72.1%), with a median (IQR) age of 37 (30-45) years. MSM accounted for 42.2% of cases, followed by heterosexuals (36.4%). Non-B subtype infections accounted for 30.8% of the overall population and increased over time (<2005-14: 19.5%-38.5%, P < 0.0001), particularly among Italians (<2005-14: 6.5%-28.8%, P < 0.0001). TDR prevalence was 8.8% and increased over time in non-B subtypes (<2005-14: 2%-7.1%, P = 0.018). Overall, 467 transmission clusters (involving 1207 individuals; 27.9%) were identified. The prevalence of individuals grouping in transmission clusters increased over time in both B (<2005-14: 12.9%-33.5%, P = 0.001) and non-B subtypes (<2005-14: 18.4%-41.9%, P = 0.006). TDR transmission clusters were 13.3% within the overall cluster observed and dramatically increased in recent years (<2005-14: 14.3%-35.5%, P = 0.005). This recent increase was mainly due to non-B subtype-infected individuals, who were also more frequently involved in large transmission clusters than those infected with a B subtype [median number of individuals in transmission clusters: 7 (IQR 6-19) versus 4 (3-4), P = 0.047]. Conclusions The epidemiology of HIV transmission changed greatly over time; the increasing number of transmission clusters (sometimes with drug resistance) shows that detection and proper treatment of the multi-transmitters is a major target for controlling HIV spread.

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U2 - 10.1093/jac/dkx231

DO - 10.1093/jac/dkx231

M3 - Article

AN - SCOPUS:85030668010

VL - 72

SP - 2837

EP - 2845

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

SN - 0305-7453

IS - 10

ER -