TY - JOUR
T1 - Dynamics of HIV viral load in blood and semen of patients under HAART
T2 - Impact of therapy in assisted reproduction procedures
AU - La Sala, Giovanni Battista
AU - Pilotti, Elisabetta
AU - Nicoli, Alessia
AU - Pinelli, Silvana
AU - Villani, Maria Teresa
AU - Ronzi, Paola
AU - Zendri, Enrico
AU - Re, Maria Carla
AU - Magnani, Giacomo
AU - Casoli, Claudio
PY - 2007/1
Y1 - 2007/1
N2 - We examined the efficacy and effect of HAART in HIV-1-infected men confronted with assisted fertilization procedures. We showed that HAART did not always reduce the HIV-1-RNA level in blood and semen compartments, and that a significant upward shift in mitochondrial DNA was observed in spermatozoa from a HAART-treated patient group compared with spermatozoa from HAART-untreated or HIV-1-uninfected groups (P <0.001). These findings emphasize the negative role of HAART, but not of HIV-1 infection, in determining semen alterations.
AB - We examined the efficacy and effect of HAART in HIV-1-infected men confronted with assisted fertilization procedures. We showed that HAART did not always reduce the HIV-1-RNA level in blood and semen compartments, and that a significant upward shift in mitochondrial DNA was observed in spermatozoa from a HAART-treated patient group compared with spermatozoa from HAART-untreated or HIV-1-uninfected groups (P <0.001). These findings emphasize the negative role of HAART, but not of HIV-1 infection, in determining semen alterations.
UR - http://www.scopus.com/inward/record.url?scp=33846601413&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33846601413&partnerID=8YFLogxK
U2 - 10.1097/QAD.0b013e328012ccfb
DO - 10.1097/QAD.0b013e328012ccfb
M3 - Article
C2 - 17255749
AN - SCOPUS:33846601413
VL - 21
SP - 377
EP - 379
JO - AIDS
JF - AIDS
SN - 0269-9370
IS - 3
ER -