Dynamics of HIV viral load in blood and semen of patients under HAART: Impact of therapy in assisted reproduction procedures

Giovanni Battista La Sala, Elisabetta Pilotti, Alessia Nicoli, Silvana Pinelli, Maria Teresa Villani, Paola Ronzi, Enrico Zendri, Maria Carla Re, Giacomo Magnani, Claudio Casoli

Research output: Contribution to journalArticlepeer-review

Abstract

We examined the efficacy and effect of HAART in HIV-1-infected men confronted with assisted fertilization procedures. We showed that HAART did not always reduce the HIV-1-RNA level in blood and semen compartments, and that a significant upward shift in mitochondrial DNA was observed in spermatozoa from a HAART-treated patient group compared with spermatozoa from HAART-untreated or HIV-1-uninfected groups (P <0.001). These findings emphasize the negative role of HAART, but not of HIV-1 infection, in determining semen alterations.

Original languageEnglish
Pages (from-to)377-379
Number of pages3
JournalAIDS (London, England)
Volume21
Issue number3
DOIs
Publication statusPublished - Jan 2007

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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