Dynamics of pleural fluid effusion and chylothorax in the fetus and newborn: Role of the lymphatic system

Cario Bellini, Z. Ergaz, F. Boccardo, T. Bellini, C. C. Campisi, E. Bonioli, L. A. Ramenghi

Research output: Contribution to journalArticlepeer-review

Abstract

Pleural fluid effusion particularly chylothorax is a relatively rare occurrence in the newborn, but when it occurs it is often life-threatening. In this article, we describe and illustrate the morphologic features of the visceral and parietal pleura including pleural lymphatics and the physiology and pathophysiology of pleural fluid balance. The role and function of the lymphatic system in controlling the volume and composition of pleural liquid are detailed and a conceptual scheme presented. Finally, the crucial role of inadequate lymphatic drainage (either functional overload from an imbalance in Starling forces or mechanical insufficiency from lymphatic dysplasia) is emphasized.

Original languageEnglish
Pages (from-to)75-84
Number of pages10
JournalLymphology
Volume46
Issue number2
Publication statusPublished - 2013

Keywords

  • Congenital chylothorax
  • Hydrops fetalis
  • Lymph dynamics
  • Lymphatic dysplasia
  • Newborn
  • Pathophysiology
  • Perinatal pleural effusions

ASJC Scopus subject areas

  • Immunology and Allergy
  • Hematology
  • Medicine(all)

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