Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection

Filippo Caraci, Simona Spampinato, Maria Angela Sortino, Paolo Bosco, Giuseppe Battaglia, Valeria Bruno, Filippo Drago, Ferdinando Nicoletti, Agata Copani

Research output: Contribution to journalArticle

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder that affects about 35 million people worldwide. Current drugs for AD only treat the symptoms and do not interfere with the underlying pathogenic mechanisms of the disease. AD is characterized by the presence of β-amyloid (Aβ) plaques, neurofibrillary tangles, and neuronal loss. Identification of the molecular determinants underlying Aβ-induced neurodegeneration is an essential step for the development of disease-modifying drugs. Recently, an impairment of the transforming growth factor-β1 (TGF-β1) signaling pathway has been demonstrated to be specific to the AD brain and, particularly, to the early phase of the disease. TGF-β1 is a neurotrophic factor responsible for the initiation and maintenance of neuronal differentiation and synaptic plasticity. The deficiency of TGF-β1 signaling is associated with Aβ pathology and neurofibrillary tangle formation in AD animal models. Reduced TGF-β1 signaling seems to contribute both to microglial activation and to ectopic cell-cycle re-activation in neurons, two events that contribute to neurodegeneration in the AD brain. The neuroprotective features of TGF-β1 indicate the advantage of rescuing TGF-β1 signaling as a means to slow down the neurodegenerative process in AD.

Original languageEnglish
Pages (from-to)291-301
Number of pages11
JournalCell & Tissue Research
Volume347
Issue number1
DOIs
Publication statusPublished - Jan 2012

Keywords

  • β-Amyloid
  • Alzheimer's disease
  • Apoptosis
  • Cell cycle activation
  • Neuroprotection
  • Transforming growth factor-β1

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology
  • Histology

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