Dysfunctional neural networks associated with impaired social interactions in early psychosis: An ICA analysis

Monica Mazza, Alessia Catalucci, Maria Chiara Pino, Laura Giusti, Anna Nigri, Rocco Pollice, Rita Roncone, Massimo Casacchia, Massimo Gallucci

Research output: Contribution to journalArticle

Abstract

The "default mode", or baseline of brain function is a topic of great interest in schizophrenia research. Recent neuroimaging studies report that the symptoms of chronic schizophrenia subjects are associated with temporal frequency alterations as well as with the disruption of local spatial patterns in the default mode network (DMN). Previous studies both on chronic and medicated subjects with psychosis suffered from limitations; on this basis, it was hypothesized that the default mode network showed abnormal activation and connectivity in young and neuroleptic-naïve patients with first-episode psychosis. This study investigated emotional responses to pleasant and unpleasant/disgusting visual stimuli by a resting-state analysis of fMRI-data from 12 untreated first-episode psychosis patients with prevalently negative symptomatology versus 12 healthy subjects. We chose this experimental task to explore the functional link between default mode network and hedonic processing which has been proposed as a marker of cerebral dysfunction in psychotic disorder and implicated in its pathophysiology. Independent Component Analysis (ICA) was used to identify the default mode component. Both healthy and first-episode subjects showed significant spatial differences in the default mode network. In first-episode subjects, medial frontal hypoactivity and cerebellar hyperactivity were correlated with the severity of negative symptoms.

Original languageEnglish
Pages (from-to)248-259
Number of pages12
JournalBrain Imaging and Behavior
Volume7
Issue number3
DOIs
Publication statusPublished - Sep 2013

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Interpersonal Relations
Psychotic Disorders
Schizophrenia
Pleasure
Neuroimaging
Antipsychotic Agents
Healthy Volunteers
Magnetic Resonance Imaging
Brain
Research

Keywords

  • Default Mode Network
  • First-episode
  • fMRI
  • Hedonic Processing
  • Psychosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Neurology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience
  • Behavioral Neuroscience
  • Radiology Nuclear Medicine and imaging

Cite this

Mazza, M., Catalucci, A., Pino, M. C., Giusti, L., Nigri, A., Pollice, R., ... Gallucci, M. (2013). Dysfunctional neural networks associated with impaired social interactions in early psychosis: An ICA analysis. Brain Imaging and Behavior, 7(3), 248-259. https://doi.org/10.1007/s11682-013-9223-6

Dysfunctional neural networks associated with impaired social interactions in early psychosis : An ICA analysis. / Mazza, Monica; Catalucci, Alessia; Pino, Maria Chiara; Giusti, Laura; Nigri, Anna; Pollice, Rocco; Roncone, Rita; Casacchia, Massimo; Gallucci, Massimo.

In: Brain Imaging and Behavior, Vol. 7, No. 3, 09.2013, p. 248-259.

Research output: Contribution to journalArticle

Mazza, M, Catalucci, A, Pino, MC, Giusti, L, Nigri, A, Pollice, R, Roncone, R, Casacchia, M & Gallucci, M 2013, 'Dysfunctional neural networks associated with impaired social interactions in early psychosis: An ICA analysis', Brain Imaging and Behavior, vol. 7, no. 3, pp. 248-259. https://doi.org/10.1007/s11682-013-9223-6
Mazza, Monica ; Catalucci, Alessia ; Pino, Maria Chiara ; Giusti, Laura ; Nigri, Anna ; Pollice, Rocco ; Roncone, Rita ; Casacchia, Massimo ; Gallucci, Massimo. / Dysfunctional neural networks associated with impaired social interactions in early psychosis : An ICA analysis. In: Brain Imaging and Behavior. 2013 ; Vol. 7, No. 3. pp. 248-259.
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