Dysphagia in huntington's disease: Correlation with clinical features

Marina De Tommaso, Angela Nuzzi, Anna Rita Dellomonaco, Vittorio Sciruicchio, Claudia Serpino, Claudia Cormio, Giovanni Franco, Marisa Megna

Research output: Contribution to journalArticlepeer-review

Abstract

Huntington's disease (HD) is an inherited neurodegenerative disorder characterised by motor impairment, cognitive decline and psychiatric disorders. Dysphagia is a pathologic condition that increases morbidity and mortality of the affected people. Our aim was to evaluate dysphagia in a group of HD patients in view of motor, cognitive and functional decline. Thirty-seven genetically confirmed HD patients were submitted to clinical evaluations of swallowing. Bedside Swallowing Assessment Scale (BSAS) was used. Dysphagia Outcome and Severity Scale (DOSS) was applied for a preliminary classification of swallowing difficulties. All patients were also evaluated by the Unified Huntington's Disease Rating Scale (UHDRS). A group of 39 controls comparable for sex and age were recruited for BSAS scores normalisation. The BSAS scores indicated that in our HD cohort, 32.4% presented relevant or severe dysphagia. The DOSS levels were significantly correlated with main clinical features, such as age, disease duration and motor impairment, with special regard to lingual protrusion ability, dysarthria and bradykinesia. The total functional capacity (TFC) and cognitive scales did not show significant correlation with DOSS levels. The results of clinical examination of swallowing indicated that dysphagia is a prevalent motor symptom of HD.

Original languageEnglish
Pages (from-to)49-53
Number of pages5
JournalEuropean Neurology
Volume74
DOIs
Publication statusPublished - Sep 22 2015

Keywords

  • Dysphagia
  • Huntington's disease
  • Movement disorders

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Fingerprint Dive into the research topics of 'Dysphagia in huntington's disease: Correlation with clinical features'. Together they form a unique fingerprint.

Cite this