Dysplastic neocortex and subcortical heterotopias in methylazoxymethanol-treated rats: An intracellular study of identified pyramidal neurones

Giulio Sancini, Silvana Franceschetti, Giorgio Battaglia, Claudia Colacitti, Monica Di Luca, Roberto Spreafico, Giuliano Avanzini

Research output: Contribution to journalArticle

Abstract

Intracellular recordings were obtained using biocytin-filled electrodes from 78 neurones located in both dysplastic neocortex and subcortical heterotopic aggregates in a model of neuronal migration disorder induced in rats by means of a double methylazoxymethanol injection given on embryonic day 15. Both regular spiking and intrinsically bursting pyramidal neurones were found in all of the examined structures and were synaptically activated by subcortical stimulation. In a neuronal subpopulation (22%) located in the neocortex as well as in the subcortical heterotopic aggregates, the injection of depolarising current pulses elicited aberrant firing patterns, consisting of repetitive bursts of APs that gradually increased in duration and eventually merged in a long-lasting discharge. The gradual development of this 'excessive' bursting behaviour suggests a progressive rundown of the slow components of the hyperpolarising afterpotential.

Original languageEnglish
Pages (from-to)181-185
Number of pages5
JournalNeuroscience Letters
Volume246
Issue number3
DOIs
Publication statusPublished - Apr 10 1998

Keywords

  • Bursting neurones
  • Cortical dysplasia
  • Epileptogenesis
  • Heterotopic aggregates
  • Methylazoxymethanol
  • Neuronal migration disorders

ASJC Scopus subject areas

  • Neuroscience(all)

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